发明授权
US5844016A Redox and photoinitiator priming for improved adherence of gels to
substrates
失效
氧化还原和光引发剂引发,以提高凝胶对底物的粘附性
- 专利标题: Redox and photoinitiator priming for improved adherence of gels to substrates
- 专利标题(中): 氧化还原和光引发剂引发,以提高凝胶对底物的粘附性
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申请号: US478104申请日: 1995-06-07
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公开(公告)号: US5844016A公开(公告)日: 1998-12-01
- 发明人: Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver
- 申请人: Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver
- 申请人地址: MA Lexington TX Austin
- 专利权人: Focal, Inc.,The Board of Regents--University of Texas System
- 当前专利权人: Focal, Inc.,The Board of Regents--University of Texas System
- 当前专利权人地址: MA Lexington TX Austin
- 主分类号: A61B17/00
- IPC分类号: A61B17/00 ; A61B17/08 ; A61L24/00 ; A61L24/04 ; A61L24/06 ; A61L29/00 ; A61L31/00 ; C08F2/48 ; C08F2/50 ; C08F4/00 ; C08F4/40 ; C08F265/04 ; C08F271/00 ; C08F283/00 ; C08F289/00 ; C08F290/06 ; C08F290/14 ; C08F291/00 ; C09D4/00 ; C09D7/00 ; C09D171/00 ; C09J151/00 ; C08F4/42
摘要:
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.
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