发明授权
- 专利标题： Acyclic anc cyclic amides as neurotransmitter release enhancers
- 专利标题（中）： 非环状酰胺作为神经递质释放增强剂
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申请号： US737376申请日： 1997-02-19
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公开(公告)号： US5854232A公开(公告)日： 1998-12-29
- 发明人: Robert A. Volkmann , Vytautas J Jasys , Gene M Bright , Anabella Villalobos , Patricia A Seymour
- 申请人： Robert A. Volkmann , Vytautas J Jasys , Gene M Bright , Anabella Villalobos , Patricia A Seymour
- 申请人地址： NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： NY New York
- 主分类号： C07D213/56
- IPC分类号： C07D213/56 ; A61K31/00 ; A61K31/215 ; A61K31/341 ; A61K31/381 ; A61K31/395 ; A61K31/415 ; A61K31/4164 ; A61K31/4166 ; A61K31/4178 ; A61K31/4192 ; A61K31/4196 ; A61K31/42 ; A61K31/44 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; A61K31/4418 ; A61K31/4427 ; A61K31/443 ; A61K31/4439 ; A61K31/495 ; A61K31/4965 ; A61K31/497 ; A61K31/505 ; A61K31/506 ; A61P25/00 ; A61P25/16 ; A61P25/18 ; A61P25/22 ; A61P25/28 ; A61P25/30 ; A61P43/00 ; C07C233/06 ; C07D213/20 ; C07D231/12 ; C07D233/76 ; C07D239/26 ; C07D241/12 ; C07D249/04 ; C07D249/08 ; C07D261/08 ; C07D307/16 ; C07D307/54 ; C07D333/24 ; C07D401/06 ; C07D401/14 ; C07D405/06 ; C07D405/14 ; C07D413/06
摘要：
This invention relates to compounds of formula (IA), (IB), (IC) or (ID), wherein m, X, Z, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.14 and the dotted lines are as defined below, their pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of using them to treat Alzheimer's disease, age-associated memory impairment, Parkinson's disease and other central nervous system disorders. The claimed compounds have the ability to enhance the release of neurotransmitters such as acetylcholine, dopamine and serotonin. ##STR1##
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