发明授权
US5864026A Systematic evolution of ligands by exponential enrichment: tissue selex
失效
配体通过指数富集的系统演化：组织切除
- 专利标题： Systematic evolution of ligands by exponential enrichment: tissue selex
- 专利标题（中）： 配体通过指数富集的系统演化：组织切除
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申请号： US437667申请日： 1995-05-03
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公开(公告)号： US5864026A公开(公告)日： 1999-01-26
- 发明人: Kirk Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
- 申请人： Kirk Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
- 申请人地址： CO Boulder
- 专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人地址： CO Boulder
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07B61/00 ; C07H19/06 ; C07H19/10 ; C07H21/00 ; C07K7/22 ; C07K14/00 ; C07K14/16 ; C07K14/72 ; C12N9/12 ; C12N15/10 ; C12N15/115 ; C12Q1/37 ; C12Q1/68 ; C12Q1/70 ; F02B75/02 ; G01N33/53 ; G01N33/531 ; G01N33/532 ; G01N33/535 ; G01N33/569 ; G01N33/68 ; G01N33/76 ; C07H21/04 ; C07H21/02 ; C12P19/34
摘要：
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.
公开/授权文献
- US4451365A Column clamping device for chromatography 公开/授权日：1984-05-29
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