发明授权
US5871959A Method of producing hepatocycte growth factor/scatter factor and related
cell lines
失效
生产肝细胞生长因子/分散因子和相关细胞系的方法
- 专利标题： Method of producing hepatocycte growth factor/scatter factor and related cell lines
- 专利标题（中）： 生产肝细胞生长因子/分散因子和相关细胞系的方法
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申请号： US344710申请日： 1994-11-18
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公开(公告)号： US5871959A公开(公告)日： 1999-02-16
- 发明人: Sing Rong , George Vande Woude , Donna L. Faletto , Ilan Tsarfaty , Marianne Oskarsson
- 申请人： Sing Rong , George Vande Woude , Donna L. Faletto , Ilan Tsarfaty , Marianne Oskarsson
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： C07K14/475
- IPC分类号： C07K14/475 ; C12N5/00 ; C12N15/00 ; C12N15/73 ; C12N15/79
摘要：
A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.
公开/授权文献
- US4960273A Dual mode document feeder 公开/授权日：1990-10-02
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