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    Method of producing hepatocycte growth factor/scatter factor and related cell lines
    1.
    发明授权
    Method of producing hepatocycte growth factor/scatter factor and related cell lines 失效
    生产肝细胞生长因子/分散因子和相关细胞系的方法

    公开(公告)号：US5871959A

    公开(公告)日：1999-02-16

    申请号：US344710

    申请日：1994-11-18

    申请人： Sing Rong ,  George Vande Woude ,  Donna L. Faletto ,  Ilan Tsarfaty ,  Marianne Oskarsson

    发明人： Sing Rong ,  George Vande Woude ,  Donna L. Faletto ,  Ilan Tsarfaty ,  Marianne Oskarsson

    IPC分类号： C07K14/475 ,  C12N5/00 ,  C12N15/00 ,  C12N15/73 ,  C12N15/79

    CPC分类号： C07K14/4753

    摘要： A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

    摘要翻译： 描述了通过抑制肝细胞生长因子/分散因子（“HGF / SF”）与蛋白原癌基因蛋白的结合来预防肿瘤细胞转移的方法。 还描述了生产HGF / SF的方法和用于生产HGF / SF的细胞系。 met原癌基因酪氨酸激酶受体（Met）及其配体，肝细胞生长因子/分散因子（HGF / SF）通常构成旁分泌信号系统，其中间质原始细胞产生配体，其与受体结合 主要表达于上皮细胞。 本发明的方法破坏有助于间质起源的肿瘤如肉瘤中的致瘤过程的Met-HGF / SF自分泌信号传导。

    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus
    4.
    发明授权
    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus 有权
    疫苗施用方法，新的猫科动物病毒和用于免疫动物抗猫病毒和猫疱疹病毒的治疗

    公开(公告)号：US07790169B2

    公开(公告)日：2010-09-07

    申请号：US11494825

    申请日：2006-07-28

    申请人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    发明人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    IPC分类号： A61A35/00 ,  C12N7/00

    CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2750/10034 ,  C12N2750/14334 ,  C12N2770/16021 ,  C12N2770/16022 ,  C12N2770/16034 ,  G01N33/56983 ,  G01N2469/10

    摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.

    摘要翻译： 本发明涉及用于免疫猫对猫科动物病毒的疫苗。 本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。 本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体 包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。 本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。 还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。 该方法包括给予猫治疗有效量的第一和第二FCV疫苗。 第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。 第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。 也可以给予第三次疫苗管理。 本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒 称为猫科鼻气管炎病毒。

    METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS
    5.
    发明申请
    METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS 有权
    疫苗管理方法，新疫苗药物和用于免疫动物疫苗的疫苗和疫苗病毒的治疗方法

    公开(公告)号：US20110052619A1

    公开(公告)日：2011-03-03

    申请号：US12824287

    申请日：2010-06-28

    申请人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    发明人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    IPC分类号： A61K39/125 ,  A61P31/14

    CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2750/10034 ,  C12N2750/14334 ,  C12N2770/16021 ,  C12N2770/16022 ,  C12N2770/16034 ,  G01N33/56983 ,  G01N2469/10

    摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.

    摘要翻译： 本发明涉及用于免疫猫对猫科动物病毒的疫苗。 本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。 本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体 包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。 本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。 还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。 该方法包括给予猫治疗有效量的第一和第二FCV疫苗。 第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。 第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。 也可以给予第三次疫苗管理。 本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒 称为猫科鼻气管炎病毒。

    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus
    6.
    发明申请
    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus 有权
    疫苗施用方法，新的猫科动物病毒和用于免疫动物抗猫病毒和猫疱疹病毒的治疗

    公开(公告)号：US20070031454A1

    公开(公告)日：2007-02-08

    申请号：US11494825

    申请日：2006-07-28

    申请人： David Lowery ,  Sing Rong ,  Paul Guimond ,  Paula Clare ,  Cassius Tucker ,  Thomas Newby

    发明人： David Lowery ,  Sing Rong ,  Paul Guimond ,  Paula Clare ,  Cassius Tucker ,  Thomas Newby

    IPC分类号： A61K39/125 ,  A61K48/00

    CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2750/10034 ,  C12N2750/14334 ,  C12N2770/16021 ,  C12N2770/16022 ,  C12N2770/16034 ,  G01N33/56983 ,  G01N2469/10

    摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.

    摘要翻译： 本发明涉及用于免疫猫对猫科动物病毒的疫苗。 本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。 本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体 包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。 本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。 还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。 该方法包括给予猫治疗有效量的第一和第二FCV疫苗。 第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。 第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。 也可以给予第三次疫苗管理。 本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒 称为猫科鼻气管炎病毒。

    Processes for preparation of Marek's Disease using continuous mammalian cell lines
    7.
    发明授权
    Processes for preparation of Marek's Disease using continuous mammalian cell lines 失效
    使用连续哺乳动物细胞系制备马立克氏病的方法

    公开(公告)号：US06475770B1

    公开(公告)日：2002-11-05

    申请号：US09587835

    申请日：2000-06-06

    申请人： Sing Rong ,  Michael G. Sheppard

    发明人： Sing Rong ,  Michael G. Sheppard

    IPC分类号： C12N15869

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/255 ,  C12N7/00 ,  C12N2710/16334 ,  C12N2710/16343

    摘要： The present invention relates to mammalian cell lines which efficiently support the growth and productive infection of Marek's Disease Virus at high titers. The present invention also relates to mammalian cell lines which have been engineered to support the growth and productive infection of recombinant Marek's Disease Virus at high titers. The present invention relates a process for the preparation of Marek's Disease Virus in quantities suitable for vaccine purposes.

    摘要翻译： 本发明涉及以高滴度有效地支持马立克氏病病毒的生长和生产性感染的哺乳动物细胞系。 本发明还涉及已经被工程化以支持重度马立克氏病病毒在高滴度下的生长和生产性感染的哺乳动物细胞系。 本发明涉及用于制备适合于疫苗用途的量的马立克氏病病毒的方法。