发明授权
- 专利标题: APP770 mutant in alzheimer's disease
- 专利标题(中): APP770突变体在阿尔茨海默病
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申请号: US104165申请日: 1992-01-21
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公开(公告)号: US5877015A公开(公告)日: 1999-03-02
- 发明人: John Anthony Hardy , Marie-Christine Chartier-Harlin , Alison Mary Goate , Michael John Owen , Michael John Mullan
- 申请人: John Anthony Hardy , Marie-Christine Chartier-Harlin , Alison Mary Goate , Michael John Owen , Michael John Mullan
- 申请人地址: GB2 London
- 专利权人: Imperial College of Science, Technology of Medicine
- 当前专利权人: Imperial College of Science, Technology of Medicine
- 当前专利权人地址: GB2 London
- 优先权: GBX9101307 19910121; GBX9118445 19910828
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A01K67/00 ; A01K67/027 ; A61P25/28 ; C07K14/00 ; C07K14/47 ; C07K14/575 ; C07K16/00 ; C12N1/21 ; C12N5/10 ; C12N15/00 ; C12N15/09 ; C12N15/12 ; C12N15/85 ; C12P21/02 ; C12Q1/02 ; C12Q1/68 ; G01N33/15 ; G01N33/50 ; G01N33/53 ; C07H21/04
摘要:
Model systems of Alzheimer's disease comprise a DNA sequence encoding an amyloid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be other than valine at the amino acid position corresponding to amino acid residue position 717 of APP770. Methods of determining genetic predisposition to Alzheimer's disease are also disclosed.