发明授权
US6071510A Modified amino acids and compositions comprising the same for delivering
active agents
失效
修饰的氨基酸和包含其的组合物用于递送活性剂
- 专利标题： Modified amino acids and compositions comprising the same for delivering active agents
- 专利标题（中）： 修饰的氨基酸和包含其的组合物用于递送活性剂
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申请号： US839094申请日： 1997-04-23
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公开(公告)号： US6071510A公开(公告)日： 2000-06-06
- 发明人: Andrea Leone-Bay , Koc-Kan Ho , Jeffery Bruce Press , Nai-Fang Wang
- 申请人： Andrea Leone-Bay , Koc-Kan Ho , Jeffery Bruce Press , Nai-Fang Wang
- 申请人地址： NY Tarrytown
- 专利权人： Emisphere Technologies, Inc.
- 当前专利权人： Emisphere Technologies, Inc.
- 当前专利权人地址： NY Tarrytown
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/16 ; A61K38/21 ; A61K38/23 ; A61K38/27 ; A61K38/29 ; A61K47/18 ; A61K47/20 ; A61K47/22 ; C07C233/34 ; C07C233/47 ; C07C233/48 ; C07C233/51 ; C07C233/52 ; C07C233/54 ; C07C233/55 ; C07C233/63 ; C07C233/81 ; C07C233/83 ; C07C233/84 ; C07C233/87 ; C07C235/24 ; C07C235/34 ; C07C235/38 ; C07C235/40 ; C07C235/60 ; C07C235/64 ; C07C235/82 ; C07C237/22 ; C07C237/40 ; C07C237/42 ; C07C259/06 ; C07C271/22 ; C07C309/59 ; C07C311/19 ; C07D207/34 ; C07D213/81 ; C07D295/215 ; C07D317/68 ; C07D333/38 ; A61K31/70 ; A61K38/17 ; A61K47/12 ; C07C229/06
摘要：
The present invention provides modified amino acids for delivering active agents, and particularly biologically or chemically active agents. The preferred modified amino acids of the present invention include N-acylated or sulfonated amino acids. These modified amino acids are used as carriers to facilitate the delivery of a cargo to a target. Such modified amino acids are well suited to form non-covalent mixtures with biologically-active agents for oral administration to animals. Methods for the preparation and administration of the modified amino acids and compositions including the same are also provided.