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公开(公告)号：US09822206B2
公开(公告)日：2017-11-21
申请号：US13822976
申请日：2010-09-14
IPC分类号： C08F220/36 , C08F220/60 , C08F226/06 , C08F212/10 , C08F220/50 , B41C1/10 , C07C233/84 , C07C255/19 , C07C275/34 , C07C275/42 , C07C311/46 , C07D207/40 , C07D209/86 , C07D233/74 , C07D295/215 , C08F12/22 , C08F12/24 , C08F12/26 , C08F12/30 , C08F212/14 , C08F220/06 , C08F220/14 , C09D125/18 , G03F7/004 , C08F2/46 , C08F220/38 , C08F220/34
CPC分类号： C08F226/06 , B41C1/1008 , B41C2210/02 , B41C2210/08 , B41C2210/22 , B41C2210/24 , C07C233/54 , C07C233/84 , C07C255/19 , C07C275/34 , C07C275/42 , C07C311/46 , C07D207/40 , C07D209/86 , C07D233/74 , C07D295/215 , C08F2/46 , C08F12/22 , C08F12/24 , C08F12/26 , C08F12/30 , C08F212/10 , C08F212/14 , C08F220/06 , C08F220/14 , C08F220/36 , C08F220/50 , C08F2220/343 , C08F2220/346 , C08F2220/387 , C08F2220/603 , C08F2220/606 , C09D125/18 , G03F7/004 , C08F2220/1808 , C08F220/18
摘要： There is provided a copolymer having the general structure below, wherein a, b, and d are molar ratios varying between about 0.01 and about 0.90 and c is a molar ratio varying between about 0.01 and about 0.90; A1 represents monomer units comprising a cyano-containing pendant group in which the cyano is not directly attached to the backbone of the copolymer; A2 represents monomer units comprising two or more hydrogen bonding sites; A3 represents monomer units that increase solubility in organic solvents; and A4 represents monomer units that increase solubility in aqueous alkaline solutions. There is also provided a near-infrared radiation-sensitive coating composition comprising this copolymer as well as a positive-working thermal lithographic printing plate comprising a near-infrared radiation-sensitive coating comprising this copolymer, a method of producing such a printing plate, and finally a method of printing using such a printing plate. Formula (I).
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公开(公告)号：US20050272815A1
公开(公告)日：2005-12-08
申请号：US11172562
申请日：2005-06-29
申请人： Andrea Leone-Bay , Koc-Kan Ho , Donald Sarubbi , Sam Milstein
发明人： Andrea Leone-Bay , Koc-Kan Ho , Donald Sarubbi , Sam Milstein
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/095 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38
CPC分类号： C07D333/38 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68
摘要： Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
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公开(公告)号：US6004992A
公开(公告)日：1999-12-21
申请号：US77259
申请日：1998-05-22
申请人： Udo Kraatz , Wolfram Andersch , Andreas Turberg , Norbert Mencke
发明人： Udo Kraatz , Wolfram Andersch , Andreas Turberg , Norbert Mencke
IPC分类号： C07D333/24 , A01N37/46 , A01N43/10 , A01N43/36 , A01N43/76 , A01N47/16 , A01N47/30 , C07C233/47 , C07C233/83 , C07C233/84 , C07C233/87 , C07C275/30 , C07D207/16 , C07D263/40 , C07D263/42 , A61K31/24 , C07C69/716 , C07C69/74
CPC分类号： A01N47/16 , A01N37/46 , A01N43/10 , A01N47/30 , C07C233/47 , C07C233/83 , C07C233/87 , C07C275/30 , C07D207/16 , C07D263/40
摘要： The present invention relates to novel fluorobutenyl aminocarboxylates of the formula (I)R--CO--O--CH.sub.2 --CH.sub.2 --CX.dbd.CF.sub.2 (I)in whichX represents hydrogen or halogen andR represents one of the groups ##STR1## (b) R.sup.3 --A--CO--NR.sup.4 --CR.sup.5 R.sup.6 -- or ##STR2## in which A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each as defined in the description, to processes for their preparation and to their use for controlling animal pests.
摘要翻译： PCT No.PCT / EP96 / 05076 Sec。 371日期：1998年5月22日 102（e）日期1998年5月22日PCT 1996年11月18日PCT公布。 第WO97 / 19599号公报 日本时间1997年6月5日本发明涉及式（I）R-CO-O-CH 2 -CH 2 -C CX = CF 2（I）的新型氟代丁烯基氨基羧酸酯，其中X表示氢或卤素，R表示其中一个 b）R3-A-CO-NR4-CR5R6-或其中A，R1，R2，R3，R4，R5和R6各自如说明书中所定义，用于其制备及其用于控制动物害虫的方法。
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公开(公告)号：US4116962A
公开(公告)日：1978-09-26
申请号：US747280
申请日：1976-12-03
IPC分类号： A61K31/195 , A61K31/215 , A61K31/22 , A61K31/40 , A61K31/405 , A61P9/12 , C07C67/00 , C07C227/16 , C07C233/84 , C07C313/00 , C07C319/02 , C07C323/58 , C07C323/60 , C07C327/20 , C07C327/22 , C07D207/10 , C07D207/16 , C07D209/16 , C07D209/20 , C07D211/32 , C07D211/60 , C07D235/16 , C07D333/04 , C07D339/04 , C07D409/06
CPC分类号： C07D211/60 , C07C323/00 , C07C327/00 , C07D207/16 , C07D209/20 , Y10S514/929 , Y10S514/96 , Y10S514/962
摘要： New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
摘要翻译： 具有通式“IMAGE”的氨基酸的新取代的酰基衍生物可用作血管紧张素转换酶抑制剂。
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5.发明申请公开(公告)号：US20100249424A1
公开(公告)日：2010-09-30
申请号：US12679382
申请日：2008-08-04
IPC分类号： C07D211/04 , C07D261/04 , C07C49/235 , C07C233/65 , C07C233/84 , C07D277/30 , C07C69/76 , C07D249/08 , C07D231/10 , C07C305/22 , C07C211/59 , C07C255/57
CPC分类号： C07D261/04 , C07C45/65 , C07C45/68 , C07C45/72 , C07C49/813 , C07C49/83 , C07C49/835 , C07C49/84 , C07C65/38 , C07C69/007 , C07C201/12 , C07C205/45 , C07D413/10 , C07D413/12 , C07D417/12
摘要： Disclosed is a method for preparing a compound of Formula 1 wherein R1 is CHX2, CX3, CX2CHX2 or CX2CX3; each X is independently Cl or F; Z is optionally substituted phenyl; and Q is phenyl or 1-naphthalenyl, each optionally substituted as defined in the disclosure; comprising contacting a compound of Formula 2 with hydroxylamine in the presence of a base.The present invention also relates to novel compounds of Formula 2, useful as starting materials for the aforedescribed method.
摘要翻译： 公开了制备式1化合物的方法，其中R1是CHX2，CX3，CX2CHX2或CX2CX3; 每个X独立地为Cl或F; Z是任选取代的苯基; 且Q为苯基或1-萘基，各自如本公开所定义; 包括在碱的存在下使式2的化合物与羟胺接触。 本发明还涉及用作上述方法的起始原料的新的式2化合物。
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公开(公告)号：US06972300B2
公开(公告)日：2005-12-06
申请号：US10623142
申请日：2003-07-18
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/195 , C07C229/00
CPC分类号： C07D333/38 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68
摘要： Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
摘要翻译： 提供了可用于递送活性剂的改性氨基酸化合物。 活性剂可以是肽，例如rhGH。 提供口服，皮下，舌下和鼻内给药的给药方法，提供修饰的氨基酸化合物的制备方法。
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公开(公告)号：US06960355B2
公开(公告)日：2005-11-01
申请号：US10005511
申请日：2001-11-07
IPC分类号： A01N37/00 , A61K9/00 , A61K9/16 , A61K9/48 , A61K38/00 , A61K38/20 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C229/42 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/69 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C235/82 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D209/48 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K9/14 , A61K9/20
CPC分类号： C07D209/48 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C229/42 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/69 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C235/82 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30
摘要： Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译： 提供了可用于递送活性剂的改性氨基酸化合物。 也提供给药和制备方法。
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公开(公告)号：US20050075378A1
公开(公告)日：2005-04-07
申请号：US10477405
申请日：2002-05-24
申请人： Lynn Gossett , Jonathan Green , James Henry , Winton Jones , Donald Matthews , Quanrong Shen , Daryl Smith , Jennifer Vance , Alan Warshawsky , Maria Gonzalez-Garcia
发明人： Lynn Gossett , Jonathan Green , James Henry , Winton Jones , Donald Matthews , Quanrong Shen , Daryl Smith , Jennifer Vance , Alan Warshawsky , Maria Gonzalez-Garcia
IPC分类号： C07D233/64 , A61K31/195 , A61K31/27 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/4035 , A61K31/415 , A61K31/4164 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/454 , A61K31/455 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P3/02 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/00 , A61P43/00 , C07C233/63 , C07C233/84 , C07C233/87 , C07C255/57 , C07C271/22 , C07C271/24 , C07D209/48 , C07D213/81 , C07D231/12 , C07D233/58 , C07D239/28 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/42 , C07D307/79 , C07D333/28 , C07D333/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04 , C07D277/18 , C07D263/52
CPC分类号： C07D209/48 , C07C233/63 , C07C233/87 , C07C255/57 , C07C271/22 , C07C271/24 , C07C2601/04 , C07C2601/14 , C07D213/81 , C07D231/12 , C07D239/28 , C07D263/32 , C07D277/28 , C07D277/42 , C07D307/79 , C07D333/28 , C07D401/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04
摘要： The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to Syndrome X as well as cardiovascular diseases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，溶剂化物，水合物或立体异构体，它们可用于治疗综合征X，II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化等 与综合征X相关的疾病以及心血管疾病。
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公开(公告)号：US5650386A
公开(公告)日：1997-07-22
申请号：US414654
申请日：1995-03-31
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K38/17 , A61K31/725 , C07C229/14
CPC分类号： C07D213/81 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/0019 , A61K9/1617 , A61K9/4858 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D295/215 , C07D317/68 , C07D333/38 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： Modified amino acid compounds useful for the delivery of active agents are provided. The amino acids, non-alpha-amino acids, have been modified by acylation on the amino group particularly with phenyl or cyclohexyl groups. These groups have a variety of substituents including but not limited to hydroxy, methyl, fluoro, chloro, and the like. The compounds of the invention can be combined with numerous active agents including but not limited to heparin, peptides, and parathyroid hormone, and can then be used for effective administration of the active agent. Administration can be, for example, oral or parenteral.
摘要翻译： 提供了可用于递送活性剂的改性氨基酸化合物。 氨基酸，非α-氨基酸已经通过氨基上的酰化，特别是用苯基或环己基进行改性。 这些基团具有多种取代基，包括但不限于羟基，甲基，氟，氯等。 本发明的化合物可以与许多活性剂组合，包括但不限于肝素，肽和甲状旁腺激素，然后可用于有效施用活性剂。 给药可以是例如口服或肠胃外。
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公开(公告)号：US06977303B2
公开(公告)日：2005-12-20
申请号：US10721714
申请日：2003-11-25
IPC分类号： B01J31/24 , C07B61/00 , C07C231/18 , C07C233/47 , C07C233/83 , C07C233/84 , C07C253/30 , C07C255/60 , C07C269/06 , C07C271/22 , C07D203/04 , C07D205/08 , C07D207/26 , C07D207/27 , C07D211/76 , C07D223/10 , C07D225/02 , C07F9/553 , C07F9/564 , C07F9/568 , C07F9/572 , C07F9/576 , C07F9/59 , C07D9/02 , C07D207/12 , C07D207/24
CPC分类号： C07D203/04 , C07B2200/07 , C07C231/18 , C07C253/30 , C07C269/06 , C07C2601/02 , C07D205/08 , C07D207/27 , C07D211/76 , C07D223/10 , C07D225/02 , C07F9/5532 , C07F9/564 , C07F9/568 , C07F9/572 , C07F9/59 , Y02P20/52 , C07C233/47 , C07C233/83 , C07C233/84 , C07C255/60 , C07C271/22
摘要： The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.
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