Invention Grant
- Patent Title: Homologous recombination for allogeneic donor cells
- Patent Title (中): 同种异体供体细胞的同源重组
-
Application No.: US443647Application Date: 1995-05-18
-
Publication No.: US6139835APublication Date: 2000-10-31
- Inventor: Raju Kucherlapati , Beverly H. Koller , Oliver Smithies , Robert B. Dubridge , Gary Greenburg , Daniel J. Capon , Steven R. Williams , Mariona Lourdes Arbones De Rafael
- Applicant: Raju Kucherlapati , Beverly H. Koller , Oliver Smithies , Robert B. Dubridge , Gary Greenburg , Daniel J. Capon , Steven R. Williams , Mariona Lourdes Arbones De Rafael
- Applicant Address: CA Foster City
- Assignee: Cell Genesys, Inc.
- Current Assignee: Cell Genesys, Inc.
- Current Assignee Address: CA Foster City
- Main IPC: A01K67/027
- IPC: A01K67/027 ; A61K35/12 ; A61K38/21 ; A61K45/00 ; C07H21/04 ; C07K14/74 ; C12N5/02 ; C12N5/10 ; C12N15/00 ; C12N15/09 ; C12N15/85 ; C12Q1/68 ; G01N33/53 ; C12N15/63
Abstract:
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2- microglobulin gene is inactivated for reducing or eliminating the expression of functional Class I MHC antigens. The resulting cells may be used as allogeneic donor cells. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.
Public/Granted literature
- USD332707S Chair Public/Granted day:1993-01-26
Information query
