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发明授权
US06878387B1 Coated medicament forms with controlled active substance release 有权
具有受控活性物质释放的涂层药物形式

Coated medicament forms with controlled active substance release
摘要：
The invention relates to a pharmaceutical preparation consisting of: (a) a core containing an active substance, optionally an excipient and common pharmaceutical additives in addition to the salt of an inorganic acid whose proportion in the weight of the core ranges from 2.5 to 97% by weight and (b) and outer film coating consisting of one or more (meth)acrylate copolymers and optionally common pharmaceutical adjuvants, wherein 40 to 100% by weight of the (meth)acrylate copolymers consist of 93 to 98% by weight of radically polymerized C1- to C4-alkylesters of acrylic or methacrylic acid and 7 to 2% by weight of (meth)acrylate monomers with a quaternary ammonium group in the alkyl radical and that may be optionally present in a mixture consisting of 1 to 60% by weight of one or more additional (meth)acrylate copolymers different from the above-mentioned (meth)acrylate copolymers, consisting of 85 to 100% by weight of a radically polymerized C1- to C4-alkylesters of acrylic orethacrylic acid and optionally and optionally up to 15% by weight of additional (meth)acrylate monomers with basic groups or acid groups in the alkyl radical.
摘要（中）：

本发明涉及一种药物制剂，其包含：（a）含有活性物质的核心，任选的赋形剂和常见的药用添加剂，除了无机酸的盐，其核心重量的比例为2.5至97％ （b）和由一种或多种（甲基）丙烯酸酯共聚物和任选的普通药用佐剂组成的外膜包衣，其中40至100重量％的（甲基）丙烯酸酯共聚物由93至98重量％ 聚合丙烯酸或甲基丙烯酸的C 1至C 4 - 烷基酯和7至2重量％的在烷基中具有季铵基团的（甲基）丙烯酸酯单体，并且其可以任选地存在于由1至60％ 一种或多种与上述（甲基）丙烯酸酯共聚物不同的另外的（甲基）丙烯酸酯共聚物的重量，其由85至100重量％的丙烯酸类聚丙烯酸酯的自由基聚合的C 1 -C 4烷基酯 酸和任选地和任选地至多15重量％的在烷基中具有碱性基团或酸基团的另外的（甲基）丙烯酸酯单体。

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