发明授权
- 专利标题： Backbone modified oligonucleotide analogues
- 专利标题（中）： 骨架修饰的寡核苷酸类似物
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申请号： US10153320申请日： 2002-05-22
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公开(公告)号： US06900301B2公开(公告)日： 2005-05-31
- 发明人: Phillip Dan Cook , Yogesh Shantilal Sanghvi , Jean Jacques Vasseur , Francoise Debart
- 申请人： Phillip Dan Cook , Yogesh Shantilal Sanghvi , Jean Jacques Vasseur , Francoise Debart
- 申请人地址： US CA Carlsbad
- 专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Isis Patent Department
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K49/00 ; C07D405/04 ; C07D405/14 ; C07F7/18 ; C07H19/04 ; C07H19/06 ; C07H19/10 ; C07H19/16 ; C07H21/00 ; C07H21/02 ; C07H21/04
摘要：
Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
公开/授权文献
- US20030045705A1 Backbone modified oligonucleotide analogues 公开/授权日：2003-03-06
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