发明授权
US06979451B1 Recombinant antigen MSP1a from anaplasma marginale to reduce infections in ticks, vaccine compositions and methods of use
失效
重组抗原MSP1a来自不定形的margin ale，以减少蜱感染，疫苗组合物和使用方法
- 专利标题： Recombinant antigen MSP1a from anaplasma marginale to reduce infections in ticks, vaccine compositions and methods of use
- 专利标题（中）： 重组抗原MSP1a来自不定形的margin ale，以减少蜱感染，疫苗组合物和使用方法
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申请号： US10285319申请日： 2002-10-31
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公开(公告)号： US06979451B1公开(公告)日： 2005-12-27
- 发明人: Jose de Jesus de la Fuente , Katherine M. Kocan , Jose Carlos Garcia-Garcia , Edmour F. Blouin
- 申请人： Jose de Jesus de la Fuente , Katherine M. Kocan , Jose Carlos Garcia-Garcia , Edmour F. Blouin
- 申请人地址： US OK Stillwater
- 专利权人： The Board of Regents for Oklahoma State University
- 当前专利权人： The Board of Regents for Oklahoma State University
- 当前专利权人地址： US OK Stillwater
- 代理机构： Fellers, Snider, Blankenship, Bailey & Tippens, P.C.
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; A01N65/00 ; A61K39/00 ; A61K39/002 ; A61K39/005 ; A61K39/02 ; A61K39/38 ; C07K14/195
摘要：
Vaccines and methods for inducing an immune response in a ruminant. The vaccine composition including pathogen and tick-derived antigens and a carrier or diluent. The method for inducing an immune response in a ruminate to provide immune protection which reduces the infection of ticks by A. marginale and/or prevents the transmission of the pathogen includes the steps of administering to the ruminant an effective amount of the vaccine composition having at least one antigen member of the group comprising at least one antigen member of the group comprising (i) recombinant MSP1a surface protein antigen of A. marginale, (ii) a subunit of recombinant MSP1a surface protein antigen of A. marginale and (iii) recombinant MSP1a surface protein antigen or subunits thereof in combination with antigen preparation derived from A. marginale infected cultured tick IDE8 cells and/or other pathogen and tick-derived antigens, and a carrier or diluent.
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