Recombinant antigen MSP1a from anaplasma marginale to reduce infections in ticks, vaccine compositions and methods of use
    4.
    发明授权
    Recombinant antigen MSP1a from anaplasma marginale to reduce infections in ticks, vaccine compositions and methods of use 失效
    重组抗原MSP1a来自不定形的margin ale,以减少蜱感染,疫苗组合物和使用方法

    公开(公告)号:US06979451B1

    公开(公告)日:2005-12-27

    申请号:US10285319

    申请日:2002-10-31

    摘要: Vaccines and methods for inducing an immune response in a ruminant. The vaccine composition including pathogen and tick-derived antigens and a carrier or diluent. The method for inducing an immune response in a ruminate to provide immune protection which reduces the infection of ticks by A. marginale and/or prevents the transmission of the pathogen includes the steps of administering to the ruminant an effective amount of the vaccine composition having at least one antigen member of the group comprising at least one antigen member of the group comprising (i) recombinant MSP1a surface protein antigen of A. marginale, (ii) a subunit of recombinant MSP1a surface protein antigen of A. marginale and (iii) recombinant MSP1a surface protein antigen or subunits thereof in combination with antigen preparation derived from A. marginale infected cultured tick IDE8 cells and/or other pathogen and tick-derived antigens, and a carrier or diluent.

    摘要翻译: 在反刍动物中诱导免疫应答的疫苗和方法。 疫苗组合物包括病原体和蜱衍生的抗原以及载体或稀释剂。 用于在反刍动物中诱导免疫应答以提供免疫保护的方法,其减少虱子的感染,并且/或防止病原体的传播包括以下步骤:向反刍动物施用有效量的疫苗组合物,其具有 该组的至少一个抗原成员包括至少一个抗原成员,其包含(i)重要的MSP1a表面蛋白抗原,(ii)重要的MSP1a表面蛋白抗原亚单位和(iii)重组 MSP1a表面蛋白抗原或其亚基与衍生自A.Repale感染的培养的蜱IDE8细胞和/或其他病原体和蜱衍生抗原的抗原制剂,以及载体或稀释剂组合。