发明授权
US07125850B2 Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
有权
鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂
- 专利标题： Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
- 专利标题（中）： 鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂
-
申请号： US11297160申请日： 2005-12-07
-
公开(公告)号： US07125850B2公开(公告)日： 2006-10-24
- 发明人: Xin Wei Wang , Curtis C. Harris , Albert J. Fornace, Jr. , Jill D. Coursen , Qimin Zhan
- 申请人： Xin Wei Wang , Curtis C. Harris , Albert J. Fornace, Jr. , Jill D. Coursen , Qimin Zhan
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Sevices
- 当前专利权人： The United States of America as represented by the Department of Health and Human Sevices
- 当前专利权人地址： US DC Washington
- 代理机构： Townsend and Townsend and Crew LLP
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/04 ; C07K7/00
摘要：
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
公开/授权文献
信息查询
IPC分类:
