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1.发明授权Methods for identifying inhibitors of GADD45 polypeptide activity and inhibitors of such activity 失效用于鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US07005419B1
公开(公告)日：2006-02-28
申请号：US10600158
申请日：2003-06-20
IPC分类号： A61K38/00
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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2.发明授权Methods for identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity 有权用于鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US06613318B1
公开(公告)日：2003-09-02
申请号：US09534811
申请日：2000-03-24
IPC分类号： A61K4500
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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3.发明授权Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity 有权鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US07125850B2
公开(公告)日：2006-10-24
申请号：US11297160
申请日：2005-12-07
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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4.发明授权Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity 失效识别GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US07438892B2
公开(公告)日：2008-10-21
申请号：US11506947
申请日：2006-08-17
IPC分类号： A61K49/00 , G01N33/53 , G01N33/574
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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5.发明申请USE OF TWO MICRORNA MOLECULARS IN LUNG CANCER PROGNOSIS AND MEDICINE PREPARATION 有权两种微阵列分子在肺癌预防和药物制备中的应用公开(公告)号：US20120220644A1
公开(公告)日：2012-08-30
申请号：US13382686
申请日：2009-07-09
申请人： Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
发明人： Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
IPC分类号： A61K31/7088 , C40B30/04 , A61P35/00 , C40B40/06
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/141 , C12N2320/10 , C12N2320/31 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.
摘要翻译： 本发明涉及两种microRNA在检测肺癌预后和药物制剂中的应用。 特别地，本发明涉及包含两个小RNA分子microRNA-150和microRNA-886-3p的组合物，包含用于检测肺癌预后的组合物和用于制备用于抑制哺乳动物和人肺癌转移的药物的装置。 具体来说，可以将microRNA-150和microRNA-886-3p的表达水平作为肺癌预后的预后标准，其中高表达水平的基因组合表示有利的治疗作用。 本发明还涉及检测哺乳动物和人肺癌中microRNA-150和microRNA-886-3p的表达水平的装置，以及检测样品中microRNA-150和microRNA-886-3p的表达水平的方法。
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6.发明授权Use of two microRNA moleculars in lung cancer prognosis and medicine preparation 有权在肺癌预后和药物制备中使用两种microRNA分子公开(公告)号：US08664191B2
公开(公告)日：2014-03-04
申请号：US13382686
申请日：2009-07-09
申请人： Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
发明人： Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/141 , C12N2320/10 , C12N2320/31 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.
摘要翻译： 本发明涉及两种microRNA在检测肺癌预后和药物制剂中的应用。 特别地，本发明涉及包含两个小RNA分子microRNA-150和microRNA-886-3p的组合物，包含用于检测肺癌预后的组合物和用于制备用于抑制哺乳动物和人肺癌转移的药物的装置。 具体来说，可以将microRNA-150和microRNA-886-3p的表达水平作为肺癌预后的预后标准，其中高表达水平的基因组合表示有利的治疗作用。 本发明还涉及检测哺乳动物和人肺癌中microRNA-150和microRNA-886-3p的表达水平的装置，以及检测样品中microRNA-150和microRNA-886-3p的表达水平的方法。
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7.发明申请Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity 失效识别GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US20060280683A1
公开(公告)日：2006-12-14
申请号：US11506947
申请日：2006-08-17
申请人： Xin Wang , Curtis Harris , Albert Fornace , Jill Coursen , Qimin Zhan
发明人： Xin Wang , Curtis Harris , Albert Fornace , Jill Coursen , Qimin Zhan
IPC分类号： A61K49/00 , G01N33/53 , G01N33/574
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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8.发明申请公开(公告)号：US20060088888A1
公开(公告)日：2006-04-27
申请号：US11297160
申请日：2005-12-07
申请人： Xin Wang , Curtis Harris , Albert Fornace , Jill Coursen , Qimin Zhan
发明人： Xin Wang , Curtis Harris , Albert Fornace , Jill Coursen , Qimin Zhan
IPC分类号： G01N33/53 , C07K14/705
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
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