公开(公告)号：US07125850B2

公开(公告)日：2006-10-24

申请号：US11297160

申请日：2005-12-07

申请人： Xin Wei Wang ,  Curtis C. Harris ,  Albert J. Fornace, Jr. ,  Jill D. Coursen ,  Qimin Zhan

发明人： Xin Wei Wang ,  Curtis C. Harris ,  Albert J. Fornace, Jr. ,  Jill D. Coursen ,  Qimin Zhan

IPC分类号： A61K38/00 ,  A61K38/04 ,  C07K7/00

CPC分类号： G01N33/5008 ,  C07K14/47 ,  G01N33/5011 ,  G01N33/68 ,  G01N33/6842 ,  G01N2500/00

摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.

摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。

公开(公告)号：US07051737B2

公开(公告)日：2006-05-30

申请号：US10773570

申请日：2004-02-05

申请人： Theodor Kolobow ,  Lorenzo Berra

发明人： Theodor Kolobow ,  Lorenzo Berra

IPC分类号： A61M16/00

CPC分类号： A61M16/0488 ,  A61B90/70 ,  A61B2090/701 ,  A61M16/0445 ,  A61M16/0463 ,  A61M2205/0205 ,  A61M2205/073 ,  A61M2205/32 ,  A61M2209/10

摘要： An endotracheal tube cleaning apparatus 10 which can be periodically inserted into the inside of an endotracheal tube 30 to shave away mucus deposits. In a preferred embodiment, this cleaning apparatus 10 comprises a flexible central tube 12 with an inflatable balloon 40 at its distal end. Affixed to the inflatable balloon are one or more shaving rings 70, each having a squared leading edge 72, to shave away mucus accumulations 60. In operation, the uninflated cleaning apparatus 10 is inserted into the endotracheal tube. The balloon 40 is then inflated by a suitable inflation device, such as a syringe 14, until the balloon's shaving rings are pressed against the inside surface of the endotracheal tube. The cleaning apparatus is then pulled out of the endotracheal tube to shave off mucus deposits.

摘要翻译： 气管内管清洁装置10，其可以周期性地插入到气管内管30的内部以刮除粘液沉积物。 在一个优选实施例中，该清洁装置10包括柔性中心管12，在其远端具有可充气球囊40。 与充气气囊相连的是一个或多个剃须环70，每个剃须环具有一个平方的前缘72，以刮去粘液积聚物60。 在操作中，未充气的清洁装置10插入到气管内管中。 然后通过合适的充气装置（例如注射器14）使球囊40膨胀，直到球囊的剃须环压靠气管内管的内表面。 然后将清洁装置从气管内管中拉出以刮掉粘液沉积物。

公开(公告)号：US5985655A

公开(公告)日：1999-11-16

申请号：US484126

申请日：1995-06-07

申请人： W. French Anderson ,  Leon F. Baltrucki ,  James M. Mason

发明人： W. French Anderson ,  Leon F. Baltrucki ,  James M. Mason

IPC分类号： C12N15/09 ,  A61K35/76 ,  A61K48/00 ,  C07K14/15 ,  C07K14/47 ,  C12N5/10 ,  C12N15/58 ,  C12N15/867 ,  C12N15/87 ,  C12N15/63

CPC分类号： C07K14/005 ,  C07K14/473 ,  C12N15/86 ,  C12N15/87 ,  C07K2319/00 ,  C07K2319/75 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/16222 ,  C12N2810/60 ,  C12N2810/6054 ,  C12N2810/80

摘要： A vector particle (e.g., a retroviral vector particle) containing a chimeric envelope includes a receptor binding region that binds to a receptor of a target cell. The receptor of the target cell is other than the amphotropic cell receptor. The receptor binding region may be a receptor binding region of a human virus. A portion of the envelope gene may be deleted and the deleted portion is replaced with another receptor binding region or ligand. Such vector particles are targetable to a desired target cell or tissue, and may be administered directly to the desired target cell or tissue as part of a gene therapy procedure, or administered directly into the patient.

摘要翻译： 含有嵌合包膜的载体颗粒（例如，逆转录病毒载体颗粒）包括与靶细胞的受体结合的受体结合区。 靶细胞的受体不仅是独立细胞受体。 受体结合区可以是人病毒的受体结合区。 可以缺失一部分包膜基因，并用另一个受体结合区或配体代替缺失部分。 这样的载体颗粒可靶向所需的靶细胞或组织，并且可以作为基因治疗程序的一部分直接施用于期望的靶细胞或组织，或直接施用于患者体内。