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1.发明授权Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity 失效识别GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US07438892B2
公开(公告)日：2008-10-21
申请号：US11506947
申请日：2006-08-17
IPC分类号： A61K49/00 , G01N33/53 , G01N33/574
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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2.发明授权Methods for identifying inhibitors of GADD45 polypeptide activity and inhibitors of such activity 失效用于鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US07005419B1
公开(公告)日：2006-02-28
申请号：US10600158
申请日：2003-06-20
IPC分类号： A61K38/00
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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3.发明授权Methods for identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity 有权用于鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US06613318B1
公开(公告)日：2003-09-02
申请号：US09534811
申请日：2000-03-24
IPC分类号： A61K4500
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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4.发明授权Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity 有权鉴定GADD45多肽活性抑制剂的方法和这种活性的抑制剂公开(公告)号：US07125850B2
公开(公告)日：2006-10-24
申请号：US11297160
申请日：2005-12-07
CPC分类号： G01N33/5008 , C07K14/47 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要翻译： 本发明涉及用于测定GADD45多肽活性调节剂的新方法。 本发明还提供了通过施用GADD45多肽活性的新型抑制剂使增殖细胞对DNA碱损伤剂敏感的方法。 本发明还提供了干扰Cdc2 /细胞周期蛋白B1复合物响应于GADD45在细胞周期的G2 / M阶段停止的能力的多肽，以及编码这种多肽的核酸。
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