Invention Grant
- Patent Title: Inhibitors of protein tyrosine phosphatase 1B
- Patent Title (中): 蛋白酪氨酸磷酸酶1B抑制剂
-
Application No.: US11063475Application Date: 2005-02-23
-
Publication No.: US07521473B2Publication Date: 2009-04-21
- Inventor: Jinbo Lee , Zhao-Kui Wan , Douglas P. Wilson , Bruce C. Follows , Steven J. Kirincich , Michael J. Smith , Jun-Jun Wu , Kenneth W. Foreman , David V. Erbe , Yan-Ling Zhang , Weixin Xu , Steve Y. Tam
- Applicant: Jinbo Lee , Zhao-Kui Wan , Douglas P. Wilson , Bruce C. Follows , Steven J. Kirincich , Michael J. Smith , Jun-Jun Wu , Kenneth W. Foreman , David V. Erbe , Yan-Ling Zhang , Weixin Xu , Steve Y. Tam
- Applicant Address: US NJ Madison
- Assignee: Wyeth
- Current Assignee: Wyeth
- Current Assignee Address: US NJ Madison
- Main IPC: A61K31/381
- IPC: A61K31/381 ; C07D333/38
Abstract:
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
Public/Granted literature
- US20050203087A1 Inhibitors of protein tyrosine phosphatase 1B Public/Granted day:2005-09-15
Information query
