发明授权
US07851637B2 Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
有权
抑制BCL蛋白与结合配偶体相互作用的化合物和方法
- 专利标题： Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
- 专利标题（中）： 抑制BCL蛋白与结合配偶体相互作用的化合物和方法
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申请号： US11156364申请日： 2005-06-17
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公开(公告)号： US07851637B2公开(公告)日： 2010-12-14
- 发明人: Alfredo C. Castro , Wei Deng , Kristopher M. Depew , Michael A. Foley , Christian C. Fritz , Asimina T. Georges Evangelinos , Michael J. Grogan , Nafeeza Hafeez , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Tao Liu , David A. Mann , Lisa A. Marcaurelle , Daniel A. Snyder , Dennis J. Underwood , Andrew A. Wylie , Lin-Chen Yu , Linping Zhang
- 申请人： Alfredo C. Castro , Wei Deng , Kristopher M. Depew , Michael A. Foley , Christian C. Fritz , Asimina T. Georges Evangelinos , Michael J. Grogan , Nafeeza Hafeez , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Tao Liu , David A. Mann , Lisa A. Marcaurelle , Daniel A. Snyder , Dennis J. Underwood , Andrew A. Wylie , Lin-Chen Yu , Linping Zhang
- 申请人地址： US MA Cambridge
- 专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Foley Hoag LLP
- 主分类号： C07D261/02
- IPC分类号： C07D261/02 ; A61K31/42
摘要：
One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
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