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1.发明申请Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners 失效抑制BCL蛋白与结合伙伴相互作用的化合物和方法公开(公告)号：US20130131063A1
公开(公告)日：2013-05-23
申请号：US13472136
申请日：2012-05-15
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D261/02 , C07D417/12 , A61K31/5377 , A61K31/454 , A61K31/496 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , C07D413/10 , C07D413/12 , A61K45/06
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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2.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US08178690B2
公开(公告)日：2012-05-15
申请号：US13089530
申请日：2011-04-19
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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3.发明申请Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners 有权抑制BCL蛋白与结合伙伴相互作用的化合物和方法公开(公告)号：US20110213145A1
公开(公告)日：2011-09-01
申请号：US13089530
申请日：2011-04-19
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D413/12 , C07D413/10 , C07D261/02 , C07D498/04
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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公开(公告)号：US5951564A
公开(公告)日：1999-09-14
申请号：US769198
申请日：1996-12-18
申请人： Lisa K. Schroder , David A. Mann , G. Kris Kumar , Steven C. Kitch , Paul F. Hickey , Timothy K. Doolin , Philip H. Cripe , Kim C. Bertin
发明人： Lisa K. Schroder , David A. Mann , G. Kris Kumar , Steven C. Kitch , Paul F. Hickey , Timothy K. Doolin , Philip H. Cripe , Kim C. Bertin
CPC分类号： A61F2/4607 , A61F2/367 , A61F2002/30617 , A61F2002/30795 , A61F2002/3631 , A61F2002/365 , A61F2002/368 , A61F2002/4619 , A61F2002/4622 , A61F2002/4623 , A61F2002/4628 , A61F2002/4631 , A61F2002/4681 , A61F2250/0097
摘要： The invention is directed to an orthopaedic apparatus 24, 80, 380, 480, 580 for positioning an implant 22, 322, 422 relative to an end of a bone. The implant has at least one extractor opening 30, 330, 430 and a shoulder 26, 326, 426 with a slot therein. The positioning apparatus includes a shaft 32, 82, 382, 482 having a fixed impactor tip at an end thereof. The impactor tip is configured to be received within the implant slot. At least one clamping jaw is connected to the shaft, and includes a projection which is configured to be received in the at least one extractor opening. The at least one clamping jaw is preferably detachably connected to the shaft.
摘要翻译： 本发明涉及一种用于相对于骨的端部定位植入物22,322,422的整形外科装置24,80,380,480,580。 植入物具有至少一个提取器开口30,330,430以及其中具有狭槽的肩部26,326,426。 定位装置包括在其一端具有固定的冲击器尖端的轴32,82,382,482。 冲击器尖端被配置为被接收在植入槽内。 至少一个夹爪连接到轴，并且包括被配置为容纳在至少一个提取器开口中的突起。 所述至少一个夹爪优选地可拆卸地连接到所述轴。
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公开(公告)号：USD397220S
公开(公告)日：1998-08-18
申请号：US52628
申请日：1996-03-28
申请人： G. Kris Kumar , David A. Mann
设计人： G. Kris Kumar , David A. Mann
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6.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US07928244B2
公开(公告)日：2011-04-19
申请号：US11842581
申请日：2007-08-21
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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公开(公告)号：US20100003728A1
公开(公告)日：2010-01-07
申请号：US12496013
申请日：2009-07-01
IPC分类号： C12P17/18 , C07D471/04
CPC分类号： C07J69/00 , C07D211/42 , C07D491/048 , C07H15/256 , C07J61/00 , C12P17/10 , C12P17/188
摘要： Provided are deglycosylation methods designed to optimize the yield of Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.
摘要翻译： 提供了去糖基化方法，其设计用于优化来自藜芦属植物材料和/或藜芦植物材料的提取物的藜芦生物碱的产量。
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8.发明授权Rotational alignment guide for a prosthetic hip stem implant and method of using same 失效假肢髋关节植入物的旋转对准指南及其使用方法
公开(公告)号：US5888245A
公开(公告)日：1999-03-30
申请号：US861434
申请日：1997-05-21
申请人： Steven Lee Meulink , David A. Mann
发明人： Steven Lee Meulink , David A. Mann
CPC分类号： A61F2/4657 , A61F2/30767 , A61F2/36 , A61F2/367 , A61F2/3676 , A61F2/4607 , A61F2002/30617 , A61F2002/30848 , A61F2002/30879 , A61F2002/30892 , A61F2002/3625 , A61F2002/3627 , A61F2002/3631 , A61F2002/365 , A61F2002/368 , A61F2002/4619 , A61F2002/4631 , A61F2250/0097
摘要： The invention is directed to an alignment device for aligning a prosthetic hip stem implant with an opening formed in a proximal femur. The hip stem implant includes a landmark and the proximal femur includes a visual alignment mark. The alignment device includes an implant engaging portion configured for attachment with the landmark on the hip stem implant. The alignment device also includes a needle indicator connected with the implant engaging portion and having an end which may be positioned relative to the visual alignment mark on the proximal femur, thereby aligning the prosthetic hip stem implant relative to the opening in the proximal femur.
摘要翻译： 本发明涉及一种对准装置，用于将假肢髋部植入物与在股骨近端形成的开口对准。 髋关节植入物包括地标，股骨近端包括视线对准标记。 对准装置包括植入物接合部分，该植入物接合部分构造成用于与臀部植入物上的地标相连。 对准装置还包括与植入物接合部分相连并具有相对于股骨近端上的视觉对准标记定位的端部的针指示器，从而使假体髋部植入物相对于近端股骨中的开口对准。
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9.发明授权Determination of genetic sex in ruminants using Y-chromosome specific polynucleotides 失效使用Y染色体特异性多核苷酸测定反刍动物遗传性别
公开(公告)号：US5459038A
公开(公告)日：1995-10-17
申请号：US175679
申请日：1993-12-30
申请人： Kenneth C. Reed , Eric A. Lord , Klaus I. Matthaei , David A. Mann , Sandra Beaton , Charles M. Herr , Margaret E. Matthews
发明人： Kenneth C. Reed , Eric A. Lord , Klaus I. Matthaei , David A. Mann , Sandra Beaton , Charles M. Herr , Margaret E. Matthews
CPC分类号： C12Q1/6879 , C12Q2600/156
摘要： Nucleic acid isolates capable of hybridizing only to the Y-chromosome specific DNA sequences of cattle, sheep and goats are described, as are methods for the determination of the sex chromosome constitution of a tissue or cell sample.
摘要翻译： 描述了能够仅与牛，绵羊和山羊的Y染色体特异性DNA序列杂交的核酸分离物，以及用于测定组织或细胞样品的性染色体构成的方法。
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10.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 失效抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US08609706B2
公开(公告)日：2013-12-17
申请号：US13472136
申请日：2012-05-15
申请人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： A61K31/42 , C07D261/02
CPC分类号： C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病，例如癌症。
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