发明授权
- 专利标题： Bismuth hyaluronate, the preparation method and the use thereof
- 专利标题（中）： 透明质酸铋，其制备方法及其用途
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申请号： US12095797申请日： 2006-12-01
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公开(公告)号： US08093374B2公开(公告)日： 2012-01-10
- 发明人: Peixue Ling , Yanli He , Jianying Chen , Jie Liu , Tianmin Zhang , Xueping Guo , Yan Jin
- 申请人： Peixue Ling , Yanli He , Jianying Chen , Jie Liu , Tianmin Zhang , Xueping Guo , Yan Jin
- 申请人地址： CN Shandong
- 专利权人： Peixue Ling
- 当前专利权人： Peixue Ling
- 当前专利权人地址： CN Shandong
- 代理机构： Dinsmore & Shohl LLP
- 优先权： CN200510125667 20051202
- 国际申请： PCT/CN2006/003241 WO 20061201
- 国际公布： WO2007/062595 WO 20070607
- 主分类号： C08B37/08
- IPC分类号： C08B37/08
摘要：
The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.