公开(公告)号：US08093374B2

公开(公告)日：2012-01-10

申请号：US12095797

申请日：2006-12-01

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

IPC分类号： C08B37/08

CPC分类号： A61K31/728 ,  C08B37/0072

摘要： The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

摘要翻译： 本发明公开了一种透明质酸铋，其特征在于，所述铋含量为0.5〜40％，所述葡萄糖醛酸酯含量为20〜45％。 还提供了一种制备所述透明质酸铋的方法，包括在碱性水溶液中使可溶性透明质酸盐与铋盐反应，然后进行沉淀，过滤，脱盐，脱水和干燥以获得产物。 进一步披露的是透明质酸铋在制造用于预防和治疗胃肠道疾病，特别是胃肠道溃疡性疾病的药物或保健食品中的用途。 在动物实验中已经证明比相同类型的产品显示更好的治疗效果。

公开(公告)号：US20080312429A1

公开(公告)日：2008-12-18

申请号：US12095797

申请日：2006-12-01

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

IPC分类号： C08B37/08 ,  C07H23/00

CPC分类号： A61K31/728 ,  C08B37/0072

摘要： The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

摘要翻译： 本发明公开了一种透明质酸铋，其特征在于，所述铋含量为0.5〜40％，所述葡萄糖醛酸酯含量为20〜45％。 还提供了一种制备所述透明质酸铋的方法，包括在碱性水溶液中使可溶性透明质酸盐与铋盐反应，然后进行沉淀，过滤，脱盐，脱水和干燥以获得产物。 进一步披露的是透明质酸铋在制造用于预防和治疗胃肠道疾病，特别是胃肠道溃疡性疾病的药物或保健食品中的用途。 在动物实验中已经证明比相同类型的产品显示更好的治疗效果。

公开(公告)号：US20090170808A1

公开(公告)日：2009-07-02

申请号：US12091918

申请日：2006-10-27

申请人： Peixue Ling ,  Hiafeng Yin ,  Qiuyan Jiang ,  Tianmin Zhang

发明人： Peixue Ling ,  Hiafeng Yin ,  Qiuyan Jiang ,  Tianmin Zhang

IPC分类号： A61K31/728 ,  C07H1/00

CPC分类号： A61K31/728 ,  A23L33/10 ,  A61K9/2059

摘要： The present invention relates to an oral formulation comprising a hyaluronic acid-phospholipid complex, and to use of a hyaluronic acid-phospholipid complex for the manufacture of a joint function-improving and protecting agent for oral administration which can alleviate the arthritic symptoms in patients with arthritic conditions, increase the concentration of hyaluronic acid in synovial fluid, improve the lubrication of joints, as well as maintain and enhance the normal functions of joints.

摘要翻译： 本发明涉及包含透明质酸 - 磷脂复合物的口服制剂，以及使用透明质酸 - 磷脂复合物来制造用于口服给药的关节功能改善和保护剂，其可以减轻患者的关节炎症状 关节炎症状，增加滑液中透明质酸的浓度，改善关节的润滑，维持和增强关节的正常功能。