公开(公告)号：US08093374B2

公开(公告)日：2012-01-10

申请号：US12095797

申请日：2006-12-01

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

IPC分类号： C08B37/08

CPC分类号： A61K31/728 ,  C08B37/0072

摘要： The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

摘要翻译： 本发明公开了一种透明质酸铋，其特征在于，所述铋含量为0.5〜40％，所述葡萄糖醛酸酯含量为20〜45％。 还提供了一种制备所述透明质酸铋的方法，包括在碱性水溶液中使可溶性透明质酸盐与铋盐反应，然后进行沉淀，过滤，脱盐，脱水和干燥以获得产物。 进一步披露的是透明质酸铋在制造用于预防和治疗胃肠道疾病，特别是胃肠道溃疡性疾病的药物或保健食品中的用途。 在动物实验中已经证明比相同类型的产品显示更好的治疗效果。

公开(公告)号：US20080312429A1

公开(公告)日：2008-12-18

申请号：US12095797

申请日：2006-12-01

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

IPC分类号： C08B37/08 ,  C07H23/00

CPC分类号： A61K31/728 ,  C08B37/0072

摘要： The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

摘要翻译： 本发明公开了一种透明质酸铋，其特征在于，所述铋含量为0.5〜40％，所述葡萄糖醛酸酯含量为20〜45％。 还提供了一种制备所述透明质酸铋的方法，包括在碱性水溶液中使可溶性透明质酸盐与铋盐反应，然后进行沉淀，过滤，脱盐，脱水和干燥以获得产物。 进一步披露的是透明质酸铋在制造用于预防和治疗胃肠道疾病，特别是胃肠道溃疡性疾病的药物或保健食品中的用途。 在动物实验中已经证明比相同类型的产品显示更好的治疗效果。

公开(公告)号：US08735363B2

公开(公告)日：2014-05-27

申请号：US11912123

申请日：2006-04-20

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K9/50 ,  C08B37/10

CPC分类号： C08B37/0075 ,  A61K9/14 ,  A61K31/727 ,  A61K33/38

摘要： The present invention relates to a method for preparation of heparin silver, to use of heparin silver in manufacture of medicine for treating burns and/or scalds, to a method of using heparin silver to treat burns and/or scalds, and to a topical preparation containing heparin silver for treating burns and/or scalds. The heparin silver product prepared according to the method of the present invention has a high purity and less impurity. The animal test proved that the medicine made by using heparin silver exhibited effects of accelerating wound healing and reducing scar formation.

摘要翻译： 本发明涉及肝素银制备方法，肝素银制造用于治疗烧伤和/或烫伤的药物，使用肝素银治疗烧伤和/或烫伤的方法，以及局部制剂 含有肝素银用于治疗烧伤和/或烫伤。 根据本发明的方法制备的肝素银产品具有高纯度和较少的杂质。 动物试验证明，使用肝素银制成的药物具有加速伤口愈合和减少瘢痕形成的作用。

公开(公告)号：US20080269164A1

公开(公告)日：2008-10-30

申请号：US11912123

申请日：2006-04-20

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen

IPC分类号： A61K31/727 ,  C08B37/10 ,  A61P17/02

CPC分类号： C08B37/0075 ,  A61K9/14 ,  A61K31/727 ,  A61K33/38

摘要： The present invention relates to a method for preparation of heparin silver, to use of heparin silver in manufacture of medicine for treating burns and/or scalds, to a method of using heparin silver to treat burns and/or scalds, and to a topic topical preparation containing heparin silver for treating burns and/or scalds. The heparin silver product prepared according to the method of the present invention has a high purity and less impurity. The animal test proved that the medicine made by using heparin silver exhibited effects of accelerating wound healing and reducing scar formation.

摘要翻译： 本发明涉及肝素银的制备方法，肝素银制造用于治疗烧伤和/或烫伤的药物，使用肝素银治疗烧伤和/或烫伤的方法，以及主题专题 含有肝素银的制剂用于治疗烧伤和/或烫伤。 根据本发明的方法制备的肝素银产品具有高纯度和较少的杂质。 动物试验证明，使用肝素银制成的药物具有加速伤口愈合和减少瘢痕形成的作用。

公开(公告)号：US20090170808A1

公开(公告)日：2009-07-02

申请号：US12091918

申请日：2006-10-27

申请人： Peixue Ling ,  Hiafeng Yin ,  Qiuyan Jiang ,  Tianmin Zhang

发明人： Peixue Ling ,  Hiafeng Yin ,  Qiuyan Jiang ,  Tianmin Zhang

IPC分类号： A61K31/728 ,  C07H1/00

CPC分类号： A61K31/728 ,  A23L33/10 ,  A61K9/2059

摘要： The present invention relates to an oral formulation comprising a hyaluronic acid-phospholipid complex, and to use of a hyaluronic acid-phospholipid complex for the manufacture of a joint function-improving and protecting agent for oral administration which can alleviate the arthritic symptoms in patients with arthritic conditions, increase the concentration of hyaluronic acid in synovial fluid, improve the lubrication of joints, as well as maintain and enhance the normal functions of joints.

摘要翻译： 本发明涉及包含透明质酸 - 磷脂复合物的口服制剂，以及使用透明质酸 - 磷脂复合物来制造用于口服给药的关节功能改善和保护剂，其可以减轻患者的关节炎症状 关节炎症状，增加滑液中透明质酸的浓度，改善关节的润滑，维持和增强关节的正常功能。

公开(公告)号：US20120315332A1

公开(公告)日：2012-12-13

申请号：US13519395

申请日：2009-12-28

申请人： Peixue Ling ,  Ling Zhang ,  Chenglei Shao ,  Tao Ji ,  Lixia Shang ,  Zhiping Fan

发明人： Peixue Ling ,  Ling Zhang ,  Chenglei Shao ,  Tao Ji ,  Lixia Shang ,  Zhiping Fan

IPC分类号： A61K36/28 ,  A61K9/36

CPC分类号： A61K36/28 ,  A61K31/047 ,  A61K31/19 ,  A61K31/192 ,  A61K31/194 ,  A61K31/215 ,  A61K31/352 ,  A61K31/353 ,  A61K31/365 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： A pharmaceutical composition containing sunflower extract comprises the extract of total flavonoids from leaves, heads or stems of sunflower (Helianthus annuus L.), in which the content of total flavonoids is 50-90%. Preferably, the pharmaceutical composition comprises the extract of total terpenes and/or the extract of total organic acids. The pharmaceutical composition is used as an active ingredient in manufacture of foods, functional foods or medicaments for preventing or treating hypertension.

摘要翻译： 含有向日葵提取物的药物组合物含有总黄酮提取物，其中总黄酮含量为50-90％，其中向日葵（向日葵）的叶，头或茎的总黄酮提取物。 优选地，药物组合物包含总萜烯的提取物和/或总有机酸的提取物。 药物组合物用作制造用于预防或治疗高血压的食品，功能性食品或药物的活性成分。