公开(公告)号：US20080312429A1

公开(公告)日：2008-12-18

申请号：US12095797

申请日：2006-12-01

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

IPC分类号： C08B37/08 ,  C07H23/00

CPC分类号： A61K31/728 ,  C08B37/0072

摘要： The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

摘要翻译： 本发明公开了一种透明质酸铋，其特征在于，所述铋含量为0.5〜40％，所述葡萄糖醛酸酯含量为20〜45％。 还提供了一种制备所述透明质酸铋的方法，包括在碱性水溶液中使可溶性透明质酸盐与铋盐反应，然后进行沉淀，过滤，脱盐，脱水和干燥以获得产物。 进一步披露的是透明质酸铋在制造用于预防和治疗胃肠道疾病，特别是胃肠道溃疡性疾病的药物或保健食品中的用途。 在动物实验中已经证明比相同类型的产品显示更好的治疗效果。

公开(公告)号：US20080269164A1

公开(公告)日：2008-10-30

申请号：US11912123

申请日：2006-04-20

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen

IPC分类号： A61K31/727 ,  C08B37/10 ,  A61P17/02

CPC分类号： C08B37/0075 ,  A61K9/14 ,  A61K31/727 ,  A61K33/38

摘要： The present invention relates to a method for preparation of heparin silver, to use of heparin silver in manufacture of medicine for treating burns and/or scalds, to a method of using heparin silver to treat burns and/or scalds, and to a topic topical preparation containing heparin silver for treating burns and/or scalds. The heparin silver product prepared according to the method of the present invention has a high purity and less impurity. The animal test proved that the medicine made by using heparin silver exhibited effects of accelerating wound healing and reducing scar formation.

摘要翻译： 本发明涉及肝素银的制备方法，肝素银制造用于治疗烧伤和/或烫伤的药物，使用肝素银治疗烧伤和/或烫伤的方法，以及主题专题 含有肝素银的制剂用于治疗烧伤和/或烫伤。 根据本发明的方法制备的肝素银产品具有高纯度和较少的杂质。 动物试验证明，使用肝素银制成的药物具有加速伤口愈合和减少瘢痕形成的作用。

公开(公告)号：US08735363B2

公开(公告)日：2014-05-27

申请号：US11912123

申请日：2006-04-20

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K9/50 ,  C08B37/10

CPC分类号： C08B37/0075 ,  A61K9/14 ,  A61K31/727 ,  A61K33/38

摘要： The present invention relates to a method for preparation of heparin silver, to use of heparin silver in manufacture of medicine for treating burns and/or scalds, to a method of using heparin silver to treat burns and/or scalds, and to a topical preparation containing heparin silver for treating burns and/or scalds. The heparin silver product prepared according to the method of the present invention has a high purity and less impurity. The animal test proved that the medicine made by using heparin silver exhibited effects of accelerating wound healing and reducing scar formation.

摘要翻译： 本发明涉及肝素银制备方法，肝素银制造用于治疗烧伤和/或烫伤的药物，使用肝素银治疗烧伤和/或烫伤的方法，以及局部制剂 含有肝素银用于治疗烧伤和/或烫伤。 根据本发明的方法制备的肝素银产品具有高纯度和较少的杂质。 动物试验证明，使用肝素银制成的药物具有加速伤口愈合和减少瘢痕形成的作用。

公开(公告)号：US08093374B2

公开(公告)日：2012-01-10

申请号：US12095797

申请日：2006-12-01

申请人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

发明人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

IPC分类号： C08B37/08

CPC分类号： A61K31/728 ,  C08B37/0072

摘要： The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

摘要翻译： 本发明公开了一种透明质酸铋，其特征在于，所述铋含量为0.5〜40％，所述葡萄糖醛酸酯含量为20〜45％。 还提供了一种制备所述透明质酸铋的方法，包括在碱性水溶液中使可溶性透明质酸盐与铋盐反应，然后进行沉淀，过滤，脱盐，脱水和干燥以获得产物。 进一步披露的是透明质酸铋在制造用于预防和治疗胃肠道疾病，特别是胃肠道溃疡性疾病的药物或保健食品中的用途。 在动物实验中已经证明比相同类型的产品显示更好的治疗效果。