发明授权
- 专利标题： Calicheamicin derivative-carrier conjugates
- 专利标题（中）： 加利车霉衍生物 - 载体缀合物
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申请号： US10428894申请日： 2003-05-02
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公开(公告)号： US08153768B2公开(公告)日： 2012-04-10
- 发明人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
- 申请人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
- 申请人地址： US NJ Madison
- 专利权人： Wyeth Holdings Corporation
- 当前专利权人： Wyeth Holdings Corporation
- 当前专利权人地址： US NJ Madison
- 代理机构： Womble Carlyle Sandridge & Rice, LLP
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K17/00 ; C07K16/28
摘要：
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
公开/授权文献
- US20040082764A1 Calicheamicin derivative-carrier conjugates 公开/授权日：2004-04-29