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公开(公告)号：US08835611B2
公开(公告)日：2014-09-16
申请号：US13372172
申请日：2012-02-13
申请人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
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公开(公告)号：US20120213804A1
公开(公告)日：2012-08-23
申请号：US13372172
申请日：2012-02-13
申请人： ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人： ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译： 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。
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公开(公告)号：US08747857B2
公开(公告)日：2014-06-10
申请号：US10699874
申请日：2003-11-03
申请人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
发明人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译： 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。
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公开(公告)号：US08153768B2
公开(公告)日：2012-04-10
申请号：US10428894
申请日：2003-05-02
申请人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译： 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。
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公开(公告)号：US09249184B2
公开(公告)日：2016-02-02
申请号：US13273976
申请日：2011-10-14
申请人： Paul David Robbins , Maliha Zahid
发明人： Paul David Robbins , Maliha Zahid
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to Cardiac Targeting Peptides or CTPs that are able to transduce cardiomyocytes specifically in culture and in vivo, and to methods for using such peptides and their derivatives to deliver peptides, proteins or nucleic acids specifically to the heart. It is based, at least in part, on the discovery that the peptide APWHLSSQYSRT (SEQ ID NO:1) functioned as a cardiac-specific protein targeting peptide and was successful in delivering a number of different cargoes to cardiac muscle cells in vitro and in vivo.
摘要翻译： 本发明涉及能够在培养和体内特异性转导心肌细胞的心脏靶向肽或CTP，以及使用这些肽及其衍生物将肽，蛋白质或核酸特异性递送至心脏的方法。 至少部分地基于肽APWHLSSQYSRT（SEQ ID NO：1）作为心脏特异性蛋白质靶向肽起作用并且在体外成功地将许多不同的货物递送到心肌细胞的发现，以及 体内。
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公开(公告)号：US20120244136A1
公开(公告)日：2012-09-27
申请号：US13273976
申请日：2011-10-14
申请人： Paul David Robbins , Maliha Zahid
发明人： Paul David Robbins , Maliha Zahid
IPC分类号： A61K38/10 , C07K14/52 , C07K14/475 , C07K9/00 , C07K7/08 , C07K7/06 , A61K38/14 , A61K38/08 , A61K38/18 , A61K38/19 , C12N5/077 , A61K38/43 , A61K38/47 , A61P3/00 , A61K38/44 , A61P3/06 , A61P9/00 , A61P9/10 , A61P9/06 , C12N9/96
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to Cardiac Targeting Peptides or CTPs that are able to transduce cardiomyocytes specifically in culture and in vivo, and to methods for using such peptides and their derivatives to deliver peptides, proteins or nucleic acids specifically to the heart. It is based, at least in part, on the discovery that the peptide APWHLSSQYSRT (SEQ ID NO:1) functioned as a cardiac-specific protein targeting peptide and was successful in delivering a number of different cargoes to cardiac muscle cells in vitro and in vivo.
摘要翻译： 本发明涉及能够在培养和体内特异性转导心肌细胞的心脏靶向肽或CTP，以及使用这些肽及其衍生物将肽，蛋白质或核酸特异性递送至心脏的方法。 至少部分地基于肽APWHLSSQYSRT（SEQ ID NO：1）作为心脏特异性蛋白质靶向肽起作用并且在体外成功地将许多不同的货物递送到心肌细胞的发现，以及 体内。
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7.发明授权Use of tolerogenic dendritic cells for enhancing tolerogenicity in a host and methods for making the same 有权使用耐受性树突状细胞以增强宿主中的耐受性，以及制备它们的方法公开(公告)号：US06936468B2
公开(公告)日：2005-08-30
申请号：US09844915
申请日：2001-04-27
申请人： Paul David Robbins , Lina Lu , Nick Giannoukakis
发明人： Paul David Robbins , Lina Lu , Nick Giannoukakis
CPC分类号： A61K39/001 , A61K39/0008 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12N2501/15 , C12N2501/22 , C12N2510/00 , C12N2799/022
摘要： The present invention relates to tolerogenic mammalian dendritic cells (DCs) and methods for the production of the tolerogenic DCs. In addition, the present invention provides a method for enhancing tolerogenicity in a host comprising administering the tolerogenic mammalian DCs of the present invention to the host. The tolerogenic DCs of the present invention comprise an oligodeoxyribonucleotide (ODN) which has one or more NF-κB binding sites. The tolerogenic DCs of the present invention may further comprise a viral vector, and preferably an adenoviral vector, which does not affect the tolerogenicity of the tolerogenic DCs when present therein. Enhanced tolerogenicity in a host is useful for prolonging foreign graft survival and for treating inflammatory related diseases, such as autoimmune diseases.
摘要翻译： 本发明涉及耐受性哺乳动物树突状细胞（DCs）和用于产生耐受性DC的方法。 此外，本发明提供了一种用于增强宿主中的耐受性的方法，包括将本发明的耐受性哺乳动物DC施用于宿主。 本发明的耐受性DC包含具有一个或多个NF-κB结合位点的寡脱氧核糖核苷酸（ODN）。 本发明的耐受性DC可进一步包含病毒载体，优选腺病毒载体，其不存在其中存在耐受性DC的耐受性。 宿主中增强的耐受性对于延长外来移植物存活和治疗炎性相关疾病如自身免疫性疾病是有用的。
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