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公开(公告)号:US08747857B2
公开(公告)日:2014-06-10
申请号:US10699874
申请日:2003-11-03
申请人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
发明人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译: 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数(LCF)的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物,包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物,包含缀合物的组合物和缀合物的用途。
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公开(公告)号:US08153768B2
公开(公告)日:2012-04-10
申请号:US10428894
申请日:2003-05-02
申请人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译: 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数(LCF)的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物,包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物,包含缀合物的组合物和缀合物的用途。
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公开(公告)号:US20120213804A1
公开(公告)日:2012-08-23
申请号:US13372172
申请日:2012-02-13
申请人: ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人: ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译: 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数(LCF)的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物,包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物,包含缀合物的组合物和缀合物的用途。
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公开(公告)号:US08835611B2
公开(公告)日:2014-09-16
申请号:US13372172
申请日:2012-02-13
申请人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
发明人: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
CPC分类号: A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
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5.
公开(公告)号:US08486662B2
公开(公告)日:2013-07-16
申请号:US13288260
申请日:2011-11-03
申请人: Richard Evan Gelinas , Mitra Choudhury Singhal , Yi Zhang , Andrew George Popplewell , Ralph Adams
发明人: Richard Evan Gelinas , Mitra Choudhury Singhal , Yi Zhang , Andrew George Popplewell , Ralph Adams
CPC分类号: A61K39/3955 , A61K2039/505 , C07K16/248 , C07K2316/96 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译: 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号:US20090269840A1
公开(公告)日:2009-10-29
申请号:US11928880
申请日:2007-10-30
申请人: Andrew George Popplewell , Simon Peter Tickle , Karen Zinkewich-Peotti , Robert Kendall Morrison
发明人: Andrew George Popplewell , Simon Peter Tickle , Karen Zinkewich-Peotti , Robert Kendall Morrison
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
摘要翻译: 公开了至少含有来源于对人KDR具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体,其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链,载体,转化的宿主细胞的链DNA序列以及抗体分子用于治疗其中涉及VEGF和/或KDR的疾病的用途。
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公开(公告)号:US07608694B2
公开(公告)日:2009-10-27
申请号:US10544911
申请日:2004-02-06
IPC分类号: C07K16/00 , C12P21/08 , A61K39/395 , C12P21/04
CPC分类号: C07K16/245 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1β, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
摘要翻译: 本发明涉及对IL-1β的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号:US09249232B2
公开(公告)日:2016-02-02
申请号:US12307051
申请日:2007-06-26
CPC分类号: C07K16/464 , C07K16/465 , C07K2317/24 , C07K2317/92
摘要: The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.
摘要翻译: 本发明涉及用于选择非人(供体)抗体的合适的人受体框架区的改进方法和使用这种受体框架获得高亲和力的人源化抗体的方法。
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公开(公告)号:US20120129219A1
公开(公告)日:2012-05-24
申请号:US13242429
申请日:2011-09-23
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention relates to antibody molecules having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecules and methods of producing the antibody molecules.
摘要翻译: 本发明涉及对IL-17的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途和产生抗体分子的方法。
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10.
公开(公告)号:US20120034656A1
公开(公告)日:2012-02-09
申请号:US13218857
申请日:2011-08-26
CPC分类号: C07K16/244 , A61K47/48215 , A61K47/60 , A61K2039/505 , C07K16/464 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
摘要翻译: 本发明涉及对IL-17的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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