- 专利标题： Three-dimensional structure of isoprene synthase and its use thereof for generating variants
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申请号： US12765825申请日： 2010-04-22
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公开(公告)号： US08518686B2公开(公告)日： 2013-08-27
- 发明人: Zachary Quinn Beck , Richard R. Bott , Christopher Lee Rife , Derek H. Wells , Jeffrey V. Miller
- 申请人： Zachary Quinn Beck , Richard R. Bott , Christopher Lee Rife , Derek H. Wells , Jeffrey V. Miller
- 申请人地址： US CA Palo Alto US OH Akron
- 专利权人： Danisco US Inc.,The Goodyear Tire & Rubber Company
- 当前专利权人： Danisco US Inc.,The Goodyear Tire & Rubber Company
- 当前专利权人地址： US CA Palo Alto US OH Akron
- 代理机构： Morrison & Foerster LLP
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; C12N9/88 ; C12N1/00 ; C12N15/00 ; C12P5/02 ; C07H21/04
摘要：
The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
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