- 专利标题： Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
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申请号： US11841529申请日： 2007-08-20
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公开(公告)号： US08669051B2公开(公告)日： 2014-03-11
- 发明人: Subba Reddy Palli , Mohan Basavaraju Kumar , Dean Ervin Cress , Ted Tsutomu Fujimoto
- 申请人： Subba Reddy Palli , Mohan Basavaraju Kumar , Dean Ervin Cress , Ted Tsutomu Fujimoto
- 申请人地址： US VA Blacksburg
- 专利权人： Intrexon Corporation
- 当前专利权人： Intrexon Corporation
- 当前专利权人地址： US VA Blacksburg
- 代理机构： Sterne, Kessler, Goldstein & Fox PLLC
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/567 ; C12P21/06 ; C12N5/00 ; C12N5/07 ; C12N5/02 ; C12N1/20 ; C12N1/38 ; C12N15/00 ; C07H21/04
摘要：
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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