Invention Grant
US08853154B2 Fibronectin based scaffold domain proteins that bind to myostatin
有权
结合肌生成抑制素的基于纤连蛋白的支架结构域蛋白
- Patent Title: Fibronectin based scaffold domain proteins that bind to myostatin
- Patent Title (中): 结合肌生成抑制素的基于纤连蛋白的支架结构域蛋白
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Application No.: US14025307Application Date: 2013-09-12
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Publication No.: US08853154B2Publication Date: 2014-10-07
- Inventor: Sharon Cload , Linda Engle , Dasa Lipovsek , Malavi Madireddi , Ginger Chao Rakestraw , Joanna Swain , Wenjun Zhao , Hui Wei , Aaron P. Yamniuk , Vidhyashankar Ramamurthy , Alexander T. Kozhich , Martin J. Corbett , Stanley Richard Krystek, Jr.
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Cynthia L. Kanik
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P3/04 ; A61K38/28 ; A61P5/50 ; A61P3/10 ; A61P7/12 ; A61P35/00 ; C07K1/00 ; C07K14/00 ; C07K16/00 ; C07K17/00 ; C07H21/04 ; G01N33/00 ; C12N1/20 ; C12N1/00 ; C12P21/06 ; C12N15/00 ; C12N5/07 ; C12N5/10 ; C12N5/071 ; G01N33/566 ; A61K45/06 ; C07K14/435 ; A61K38/39 ; C07K16/46 ; G01N33/74 ; A61K47/48 ; C07K14/78
Abstract:
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.
Public/Granted literature
- US20140107020A1 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN Public/Granted day:2014-04-17
Information query
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