发明授权
US08916370B2 Isoprene synthase variants for improved microbial production of isoprene
有权
异戊二烯合成酶变体用于改善异戊二烯的微生物产生
- 专利标题： Isoprene synthase variants for improved microbial production of isoprene
- 专利标题（中）： 异戊二烯合成酶变体用于改善异戊二烯的微生物产生
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申请号： US13436612申请日： 2012-03-30
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公开(公告)号： US08916370B2公开(公告)日： 2014-12-23
- 发明人: Richard R. Bott , Marguerite A. Cervin , James T. Kellis, Jr. , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Christopher Lee Rife , Derek H. Wells , Walter Weyler , Gregory M. Whited
- 申请人： Richard R. Bott , Marguerite A. Cervin , James T. Kellis, Jr. , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Christopher Lee Rife , Derek H. Wells , Walter Weyler , Gregory M. Whited
- 申请人地址： US CA Palo Alto US OH Akron
- 专利权人： Danisco US Inc.,The Goodyear Tire & Rubber Company
- 当前专利权人： Danisco US Inc.,The Goodyear Tire & Rubber Company
- 当前专利权人地址： US CA Palo Alto US OH Akron
- 代理机构： Morrison & Foerster LLP
- 主分类号： C12N9/88
- IPC分类号： C12N9/88 ; C12P21/06 ; C12N15/00 ; C12P5/02 ; C12N1/20 ; C12N1/00 ; C07H21/04 ; C07K1/00 ; C12P5/00
摘要：
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
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