发明授权
- 专利标题: Bradykinin B1-antagonists
- 专利标题(中): 缓激肽B1拮抗剂
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申请号: US12675224申请日: 2008-08-28
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公开(公告)号: US08916589B2公开(公告)日: 2014-12-23
- 发明人: Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
- 申请人: Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
- 申请人地址: DE Ingelheim am Rhein
- 专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人地址: DE Ingelheim am Rhein
- 代理商 Michael P. Morris; Anthony P. Bottino
- 优先权: DE102007041042 20070829
- 国际申请: PCT/EP2008/061263 WO 20080828
- 国际公布: WO2009/027450 WO 20090305
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; A61K31/41 ; C07D239/28 ; C07C237/24 ; C07C317/44 ; C07D209/42 ; C07D213/64 ; C07D213/82 ; C07D233/90 ; C07D237/24 ; C07D239/34 ; C07D239/36 ; C07D239/42 ; C07D261/18 ; C07D263/34 ; C07D277/56 ; C07D307/68 ; C07K5/062 ; C07K5/078
摘要:
The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as stated hereinafter, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
公开/授权文献
- US20110263626A1 NOVEL BRADYKININ B1-ANTAGONISTS 公开/授权日:2011-10-27
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