发明授权
US08951937B2 Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases
有权
鉴定和使用细菌[2Fe-2S]二羟基酸脱水酶
![Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases](/docs/US/2015-02-10/US08951937B2/abs.jpg.600x600.jpg)
- 专利标题： Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases
- 专利标题（中）： 鉴定和使用细菌[2Fe-2S]二羟基酸脱水酶
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申请号： US13838508申请日： 2013-03-15
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公开(公告)号： US08951937B2公开(公告)日： 2015-02-10
- 发明人: Dennis Flint , Steven Cary Rothman , Wonchul Suh , Jean-Francois Tomb , Rick W. Ye
- 申请人： Butamax(TM) Advanced Biofuels LLC
- 申请人地址： US DE Wilmington
- 专利权人： Butamax Advanced Biofuels LLC
- 当前专利权人： Butamax Advanced Biofuels LLC
- 当前专利权人地址： US DE Wilmington
- 主分类号： C40B30/00
- IPC分类号： C40B30/00 ; C12P21/00 ; G06F19/22 ; C12P7/16 ; C12P7/40 ; C12P13/06 ; C12P13/08 ; C12N1/21 ; C12N1/19 ; C12N9/88 ; C12N15/00 ; C12N5/10
![Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases](/abs-image/US/2015/02/10/US08951937B2/abs.jpg.150x150.jpg)
摘要：
A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing DHAD activity for conversion of 2,3-dihydroxyisovalerate to α-ketoisovalerate or 2,3-dihydroxymethylvalerate to α-ketomethylvalerate. Isobutanol and other compounds may be synthesized in pathways that include bacterial [2Fe-2S] DHAD activity.
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