发明授权
US08987271B2 2,2′-biphenazine compounds and methods useful for treating disease
有权
2,2'-联苯并嗪化合物和用于治疗疾病的方法
- 专利标题: 2,2′-biphenazine compounds and methods useful for treating disease
- 专利标题(中): 2,2'-联苯并嗪化合物和用于治疗疾病的方法
-
申请号: US13335287申请日: 2011-12-22
-
公开(公告)号: US08987271B2公开(公告)日: 2015-03-24
- 发明人: Michael H. Cardone , Xiang Y. Yu , Andrew F. Kolodziej
- 申请人: Michael H. Cardone , Xiang Y. Yu , Andrew F. Kolodziej
- 申请人地址: US MA Cambridge
- 专利权人: Eutropics Pharmaceuticals, Inc.
- 当前专利权人: Eutropics Pharmaceuticals, Inc.
- 当前专利权人地址: US MA Cambridge
- 代理机构: Cooley LLP
- 主分类号: A61K31/498
- IPC分类号: A61K31/498 ; C07D241/46 ; C07C217/92 ; C07C229/18 ; C07C229/34 ; C07C229/36 ; C07C229/48 ; C07C229/58 ; C07C229/60 ; C07C229/64 ; C07C311/21 ; C07C317/36 ; C07C317/44 ; C07D209/08 ; C07D209/34 ; C07D211/46 ; C07D211/60 ; C07D213/79 ; C07D215/48 ; C07D231/14 ; C07D231/38 ; C07D235/26 ; C07D239/28 ; C07D239/42 ; C07D261/18 ; C07D263/34 ; C07D263/48 ; C07D309/14
摘要:
The invention relates to a chemotherapeutic cancer treatment in which compounds (BH3Is) are administered to a mammal to treat B-cell Lymphoma or other hematopoietic cancers, including diseases associated with MCL-1. The invention also provides a method for treating types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more disclosed compounds in combination with other therapies, for example, 26S proteosome inhibitors, such as, for example, Bortezomib. The invention also relates to autoimmune treatment with pharmaceutical compositions comprising one or more disclosed compounds. The invention also relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease. Illustrative compounds are those of Formula II:
公开/授权文献
- US20120225851A1 COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES 公开/授权日:2012-09-06