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    COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES
    3.
    发明申请
    COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES 有权
    用于治疗疾病的组合物和方法

    公开(公告)号：US20140221387A1

    公开(公告)日：2014-08-07

    申请号：US14003733

    申请日：2012-03-08

    申请人： Michael H. Cardone ,  Andrew F. Kolodziej ,  David Richard

    发明人： Michael H. Cardone ,  Andrew F. Kolodziej ,  David Richard

    IPC分类号： C07D417/14 ,  C07D401/14 ,  C07D405/14

    CPC分类号： A61K31/4709 ,  A61K31/496 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

    摘要： The present invention relates to a compositions for and methods of cancer treatment in which compounds of Formula I or Formula II. In some aspects, the treatment of B-cell Lymphoma or other hematopoietic cancers is encompassed. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more compounds of Formula I or Formula II. Combination therapy with, for example, a class of therapeutics known as 26S proteasome inhibitors, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formula I or Formula II. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.

    摘要翻译： 本发明涉及式I或式II化合物的癌症治疗用组合物和方法。 在一些方面，包括B细胞淋巴瘤或其他造血癌的治疗。 在其它方面，本发明提供了使用一种或多种式I或式II化合物的组合来治疗特定类型的造血细胞癌例如B细胞淋巴瘤的方法。 还包括与例如称为26S蛋白酶体抑制剂的一类治疗剂例如硼替佐米的组合疗法。 另一方面，本发明涉及用式I或式II化合物进行的自身免疫治疗。 在另一方面，本发明涉及用于鉴定化合物的方法，例如BH3类似物的化合物，其具有独特的体外性质，其预测体内对B细胞淋巴瘤肿瘤和其他癌症以及自身免疫疾病的功效。

    Compositions and methods useful for treating diseases
    4.
    发明授权
    Compositions and methods useful for treating diseases 有权
    用于治疗疾病的组合物和方法

    公开(公告)号：US09051305B2

    公开(公告)日：2015-06-09

    申请号：US14003733

    申请日：2012-03-08

    申请人： Michael H. Cardone ,  Andrew F. Kolodziej ,  David Richard

    发明人： Michael H. Cardone ,  Andrew F. Kolodziej ,  David Richard

    IPC分类号： A61K31/04 ,  C07D215/38 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

    CPC分类号： A61K31/4709 ,  A61K31/496 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

    摘要： The present invention relates to a compositions for and methods of cancer treatment in which compounds of Formula I or Formula II. In some aspects, the treatment of B-cell Lymphoma or other hematopoietic cancers is encompassed. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more compounds of Formula I or Formula II. Combination therapy with, for example, a class of therapeutics known as 26S proteasome inhibitors, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formula I or Formula II. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.

    摘要翻译： 本发明涉及式I或式II化合物的癌症治疗用组合物和方法。 在一些方面，包括B细胞淋巴瘤或其他造血癌的治疗。 在其它方面，本发明提供了使用一种或多种式I或式II化合物的组合来治疗特定类型的造血细胞癌例如B细胞淋巴瘤的方法。 还包括与例如称为26S蛋白酶体抑制剂的一类治疗剂例如硼替佐米的组合疗法。 另一方面，本发明涉及用式I或式II化合物进行的自身免疫治疗。 在另一方面，本发明涉及用于鉴定化合物的方法，例如BH3类似物的化合物，其具有独特的体外性质，其预测体内对B细胞淋巴瘤肿瘤和其他癌症以及自身免疫疾病的功效。