Invention Grant
- Patent Title: Methods for controlling the galactosylation profile of recombinantly-expressed proteins
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Application No.: US14493068Application Date: 2014-09-22
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Publication No.: US09090688B2Publication Date: 2015-07-28
- Inventor: Cornelia Bengea , Lisa M. Rives , Patrick Hossler
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis
- Main IPC: C07K16/24
- IPC: C07K16/24 ; C12N5/00 ; C12P21/00 ; C07K16/00
Abstract:
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
Public/Granted literature
- US20150050693A1 METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS Public/Granted day:2015-02-19
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