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公开(公告)号：US09512214B2
公开(公告)日：2016-12-06
申请号：US14194305
申请日：2014-02-28
Applicant: ABBVIE INC.
Inventor： Lisa M. Rives , Cornelia Bengea , Xiaobei Zeng
CPC classification number: C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N2510/02 , C12P21/02
Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
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2.发明申请METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS 有权用于控制重组蛋白表达的细胞定位分析的方法公开(公告)号：US20160207992A1
公开(公告)日：2016-07-21
申请号：US15086739
申请日：2016-03-31
Applicant: AbbVie Inc.
Inventor： Cornelia Bengea , Lisa M. Rives , Patrick Hossler
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N5/0018 , C12N2500/20 , C12N2500/34 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose
Abstract translation: 本发明涉及调节重组表达蛋白质糖基化谱的方法。 特别地，本发明涉及通过用锰和/或D-半乳糖补充生产培养基（例如基于水解产物或化学定义的培养基）来控制重组表达蛋白的半乳糖基化谱的方法
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公开(公告)号：US09234033B2
公开(公告)日：2016-01-12
申请号：US14632520
申请日：2015-02-26
Applicant: ABBVIE INC.
Inventor： Lisa M. Rives , Cornelia Bengea , Xiaobei Zeng
CPC classification number: C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N2510/02 , C12P21/02
Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
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公开(公告)号：US20160138064A1
公开(公告)日：2016-05-19
申请号：US14958211
申请日：2015-12-03
Applicant: ABBVIE INC.
Inventor： Lisa M. Rives , Cornelia Bengea , Xiaobei Zeng
CPC classification number: C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/94 , C12N5/0018 , C12N15/85 , C12N2500/30 , C12N2500/32 , C12N2500/74 , C12N2500/76 , C12N2510/02 , C12N2511/00 , C12P21/00 , C12P21/005
Abstract: The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及用于控制和限制在宿主细胞中表达的蛋白质异质性的组合物和方法。
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公开(公告)号：US20150183865A1
公开(公告)日：2015-07-02
申请号：US14632520
申请日：2015-02-26
Applicant: Abbvie Inc.
Inventor： Lisa M. Rives , Cornelia Bengea , Xiaobei Zeng
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N2510/02 , C12P21/02
Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及用于控制宿主细胞中表达的蛋白质异质性的受控蛋白质异质性组合物和方法。
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Patent Agency Ranking
6.发明申请METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS 有权用于控制重组蛋白表达的细胞定位分析的方法公开(公告)号：US20150050693A1
公开(公告)日：2015-02-19
申请号：US14493068
申请日：2014-09-22
Applicant: AbbVie, Inc.
Inventor： Cornelia Bengea , Lisa M. Rives
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N5/0018 , C12N2500/20 , C12N2500/34 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
Abstract translation: 本发明涉及调节重组表达蛋白质糖基化谱的方法。 特别地，本发明涉及通过用锰和/或D-半乳糖补充生产培养基（例如基于水解产物或化学定义的培养基）来控制重组表达蛋白的半乳糖基化谱的方法。
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公开(公告)号：US09255143B2
公开(公告)日：2016-02-09
申请号：US14619799
申请日：2015-02-11
Applicant: AbbVie, Inc.
Inventor： Cornelia Bengea , Lisa M. Rives , Patrick Hossler
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N5/0018 , C12N2500/20 , C12N2500/34 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
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公开(公告)号：US20140314745A1
公开(公告)日：2014-10-23
申请号：US14194305
申请日：2014-02-28
Applicant: ABBVIE INC.
Inventor： Lisa M. Rives , Cornelia Bengea , Xiaobei Zeng
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N2510/02 , C12P21/02
Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及用于控制宿主细胞中表达的蛋白质异质性的受控蛋白质异质性组合物和方法。
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公开(公告)号：US20140065710A1
公开(公告)日：2014-03-06
申请号：US13804220
申请日：2013-03-14
Applicant: Abbvie Inc.
Inventor： Lisa M. Rives , Cornelia Bengea , Xiaobei Zeng
IPC: C12N5/00
CPC classification number: C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/94 , C12N5/0018 , C12N15/85 , C12N2500/30 , C12N2500/32 , C12N2500/74 , C12N2500/76 , C12N2510/02 , C12N2511/00 , C12P21/00 , C12P21/005
Abstract: The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及用于控制和限制在宿主细胞中表达的蛋白质异质性的组合物和方法。
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公开(公告)号：US20170137496A1
公开(公告)日：2017-05-18
申请号：US15417426
申请日：2017-01-27
Applicant: AbbVie Inc.
Inventor： Lisa M. Rives , Cornelia Bengea , Xiaobei Zeng
CPC classification number: C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/94 , C12N5/0018 , C12N15/85 , C12N2500/30 , C12N2500/32 , C12N2500/74 , C12N2500/76 , C12N2510/02 , C12N2511/00 , C12P21/00 , C12P21/005
Abstract: The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.
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