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公开(公告)号：US20170355760A1
公开(公告)日：2017-12-14
申请号：US15588211
申请日：2017-05-05
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Joseph G. Matuck , Keith Cochran , Christopher M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12N5/0037 , C12N2500/34 , C12N2510/02 , C12P21/005
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.
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公开(公告)号：US20170137860A1
公开(公告)日：2017-05-18
申请号：US15343549
申请日：2016-11-04
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Ivan Correia
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/60 , C07K2317/732 , C12N5/0018 , C12N2500/34
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
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3.发明授权公开(公告)号：US09499614B2
公开(公告)日：2016-11-22
申请号：US14209821
申请日：2014-03-13
Applicant: AbbVie, Inc.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Ivan Correia
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/60 , C07K2317/732 , C12N5/0018 , C12N2500/34
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及调节在宿主细胞中表达的蛋白质糖基化的方法和组合物。
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公开(公告)号：US20140004531A1
公开(公告)日：2014-01-02
申请号：US14016035
申请日：2013-08-30
Applicant: ABBVIE INC.
Inventor： Patrick Hossler , Ivan Correia
IPC: G01N33/68
CPC classification number: G01N33/68 , G01N33/5005 , G01N33/5023 , G01N33/56966
Abstract: The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及用于改善在宿主细胞中表达的重组蛋白的生产水平的组合物和方法。
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5.发明申请公开(公告)号：US20170226552A1
公开(公告)日：2017-08-10
申请号：US15320522
申请日：2015-07-01
Applicant: AbbVie Inc.
Inventor： Patrick Hossler , Christopher Racicot , Sean McDermott
CPC classification number: C12P21/005 , C07K16/00 , C07K16/241 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/64 , C12N1/38 , C12P21/00
Abstract: The present invention relates to the field of protein production and, in particular, to methods and compositions for modulating the glycosylation of recombinant proteins expressed in host cells using cell culture media supplemented with cobalt.
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Patent Agency Ranking
6.发明授权Methods for controlling the galactosylation profile of recombinantly-expressed proteins 有权用于控制重组表达蛋白质的半乳糖基化谱的方法公开(公告)号：US09505834B2
公开(公告)日：2016-11-29
申请号：US15086739
申请日：2016-03-31
Applicant: AbbVie Inc.
Inventor： Cornelia Bengea , Lisa M. Rives , Patrick Hossler
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N5/0018 , C12N2500/20 , C12N2500/34 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose
Abstract translation: 本发明涉及调节重组表达蛋白质糖基化谱的方法。 特别地，本发明涉及通过用锰和/或D-半乳糖补充生产培养基（例如基于水解产物或化学定义的培养基）来控制重组表达蛋白的半乳糖基化谱的方法
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公开(公告)号：US09090688B2
公开(公告)日：2015-07-28
申请号：US14493068
申请日：2014-09-22
Applicant: AbbVie Inc.
Inventor： Cornelia Bengea , Lisa M. Rives , Patrick Hossler
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N5/0018 , C12N2500/20 , C12N2500/34 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
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8.发明申请METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING SUGARS 审中-公开使用蔗糖调节重组蛋白质糖化曲线的方法公开(公告)号：US20160185848A1
公开(公告)日：2016-06-30
申请号：US14795838
申请日：2015-07-09
Applicant: ABBVIE INC.
Inventor： Patrick Hossler , Sean McDermott , Christopher Racicot , Joseph G. Matuck , Keith Cochran , Chris M. Chumsae
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12N5/0037 , C12N2500/34 , C12N2510/02 , C12P21/005
Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.
Abstract translation: 本发明涉及蛋白质生产领域，特别涉及用于调节在宿主细胞中表达的重组蛋白质糖基化的方法和组合物。
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公开(公告)号：US09255143B2
公开(公告)日：2016-02-09
申请号：US14619799
申请日：2015-02-11
Applicant: AbbVie, Inc.
Inventor： Cornelia Bengea , Lisa M. Rives , Patrick Hossler
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C12N5/0018 , C12N2500/20 , C12N2500/34 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
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10.发明申请MAMMALIAN CELL CULTURE PERFORMANCE THROUGH SURFACTANT SUPPLEMENTATION OF FEED MEDIA 审中-公开通过表面活性剂补充饲料培养基的马萨诸塞细胞培养物性能公开(公告)号：US20140271633A1
公开(公告)日：2014-09-18
申请号：US14209999
申请日：2014-03-13
Applicant: ABBVIE INC.
Inventor： Patrick Hossler
CPC classification number: C07K16/241 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/90 , C12N5/0018 , C12N2500/36 , C12N2500/50 , C12N2510/02
Abstract: The present invention provides methods for increasing cell culture performance through the use of chemically defined feed media (CDFM). In particular, the present invention provides methods for the use of surfactants as supplements to CDFM to allow for higher concentrations of media components and thereby result in increased cell culture performance.
Abstract translation: 本发明提供了通过使用化学定义的进料介质（CDFM）来提高细胞培养性能的方法。 特别地，本发明提供了使用表面活性剂作为CDFM补充剂的方法，以允许更高浓度的培养基成分，从而导致增加的细胞培养性能。
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