发明授权
- 专利标题: Anti Notch-1 antibodies
- 专利标题(中): 抗Notch-1抗体
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申请号: US13378791申请日: 2010-06-16
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公开(公告)号: US09090690B2公开(公告)日: 2015-07-28
- 发明人: Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
- 申请人: Kang Li , Ping Wei , Qinghai Peng , John Andrew Lippincott , Donna Marie Stone , Zdenek Hostomsky
- 申请人地址: US NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: US NY New York
- 代理商 Carol A. McKeever
- 国际申请: PCT/IB2010/052711 WO 20100616
- 国际公布: WO2010/146550 WO 20101223
- 主分类号: C07K16/00
- IPC分类号: C07K16/00 ; C07K16/18 ; C07K16/28 ; A61K39/00 ; A61K39/395 ; C07K14/705
摘要:
This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
公开/授权文献
- US20120093813A1 ANTI NOTCH-1 ANTIBODIES 公开/授权日:2012-04-19
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