A multi-layered film, a backsheet for photovoltaic modules, a method of manufacturing the same, and a photovoltaic module are provided. The multi-layered film can be configured so that a resin layer including a fluorine-based polymer and an oxazoline group-containing polymer is formed on a substrate. As a result, the resin layer including the fluorine-based polymer can have excellent durability and weather resistance, and show high interfacial adhesive strength to the substrate. During the preparation of the multi-layered film, a drying process can also be performed at a relatively low temperature, so that the manufacturing costs can be reduced and the quality of the product can be prevented from being deteriorated by thermal deformation or thermal shock. The multi-layered film may be effectively used as the backsheet in a variety of photovoltaic modules.