发明授权
US09120866B2 DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods
有权
DNA重组方法制备草花粉过敏原Phl p4
- 专利标题： DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods
- 专利标题（中）： DNA重组方法制备草花粉过敏原Phl p4
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申请号： US13034210申请日： 2011-02-24
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公开(公告)号： US09120866B2公开(公告)日： 2015-09-01
- 发明人: Helmut Fiebig , Andreas Nandy , Roland Suck , Oliver Cromwell , Arnd Petersen , Wolf-Meinhard Becker
- 申请人： Helmut Fiebig , Andreas Nandy , Roland Suck , Oliver Cromwell , Arnd Petersen , Wolf-Meinhard Becker
- 申请人地址： DE Darmstadt
- 专利权人： MERCK PATENT GMBH
- 当前专利权人： MERCK PATENT GMBH
- 当前专利权人地址： DE Darmstadt
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 优先权： EP02013953 20020625
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N1/12 ; C12N1/20 ; C12N15/00 ; C12N15/09 ; C12P21/04 ; C12P21/06 ; C07K14/415 ; G01N33/68 ; A61K31/7088 ; A61K39/36 ; A61K39/39 ; A61K45/06 ; A61K38/00
摘要：
The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
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