Systems and devices for sampling and profiling microbiota of skin are described which include a replaceable microbe sampling unit including at least one rotatable component, an elongated flexible strip, and a location information storage component, the elongated flexible strip including a microbe-capture region configured to capture at least one type of microbe from one or more regions of a skin surface of an individual, and the location information storage component configured to store information associated with the location of said one or more regions of the skin surface of the individual.