A high-voltage heavy-current drive circuit applied in a power factor corrector, comprising a current mirroring circuit (1), a level shift circuit (3), a high-voltage pre-modulation circuit (2), a dead time control circuit (4) and a heavy-current output stage (5); the heavy-current output stage adopts a Darlington output stage structure to increase the maximum operating frequency of the drive circuit. The stabilized breakdown voltage characteristic of a voltage stabilizing diode is utilized to ensure the drive circuit operating within a safe voltage range. Adding dead time control into the level shift circuit not only prevents the momentary heavy-current from a power supply to the ground during the level conversion process, but also reduces the static power consumption of the drive circuit.