Invention Grant
US09228227B2 Synthesis of 2′, 3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization
有权
用于自动DNA合成和焦磷酸裂解活化聚合的2',3'-双脱氧核苷合成
- Patent Title: Synthesis of 2′, 3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization
- Patent Title (中): 用于自动DNA合成和焦磷酸裂解活化聚合的2',3'-双脱氧核苷合成
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Application No.: US14173725Application Date: 2014-02-05
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Publication No.: US09228227B2Publication Date: 2016-01-05
- Inventor: Zhaochun Ma , Khairuzzaman Bashar Mullah , Robert Eason
- Applicant: LIFE TECHNOLOGIES CORPORATION
- Applicant Address: US CA Carlsbad
- Assignee: Life Technologies Corporation
- Current Assignee: Life Technologies Corporation
- Current Assignee Address: US CA Carlsbad
- Agency: Thompson Hine LLP
- Main IPC: C07D473/18
- IPC: C07D473/18 ; C12Q1/68 ; C07D405/04 ; C07D473/34 ; C07H19/16 ; C07D239/54 ; C07H19/06 ; C07H21/00 ; C07H21/02 ; C07H21/04

Abstract:
Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
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