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公开(公告)号：US11535885B2
公开(公告)日：2022-12-27
申请号：US15733557
申请日：2019-03-01
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Khairuzzaman Bashar Mullah , Brian Evans , Scott C. Benson , Chu-An Chang , Xiongwei Yan
IPC: C12Q1/68 , C12Q1/6818 , C12Q1/686
Abstract: Disclosed is a probe for use in biological assays. The probe includes a fluorescent dye bound to a quencher compound through an oligonucleotide linker. Also disclosed are methods of using the probe, such as for a polymerase chain reaction (PCR), such as in a quantitative PCR reaction (qPCR), as well as kits including the probe.
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Patent Agency Ranking
2.发明申请Synthesis Of 2' , 3' -Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization 有权用于自动DNA合成和焦磷酸分解活化聚合的2'，3'-二脱氧核苷的合成公开(公告)号：US20150045547A1
公开(公告)日：2015-02-12
申请号：US14173725
申请日：2014-02-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Zhaochun MA , Khairuzzaman Bashar Mullah , Robert Eason
CPC classification number: C07H19/16 , C07D239/54 , C07D405/04 , C07D473/18 , C07D473/34 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/6806
Abstract: Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
Abstract translation: 公开了制备2'，3'-二脱氧核苷酸支持结构的方法，例如2'，3'-二脱氧鸟苷，2'，3'-二脱氧腺苷和3'-脱氧胸苷支持结构。 还提供了使用这些结构的各种方法，例如其用于自动DNA合成和焦磷酸裂解活化聚合的用途。
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3.发明申请公开(公告)号：US20170305954A1
公开(公告)日：2017-10-26
申请号：US15643053
申请日：2017-07-06
Applicant: Life Technologies Corporation
Inventor： Zhaochun Ma , Khairuzzaman Bashar Mullah , Robert G. Eason
IPC: C07H19/16 , C07H21/04 , C07H21/02 , C07H19/06 , C07D239/54 , C07D473/34 , C07D473/18 , C07D405/04 , C12Q1/68 , C07H21/00
CPC classification number: C07H19/16 , C07D239/54 , C07D405/04 , C07D473/18 , C07D473/34 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/6806
Abstract: Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
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4.发明授权Synthesis of 2′, 3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization 有权用于自动DNA合成和焦磷酸裂解活化聚合的2'，3'-双脱氧核苷合成公开(公告)号：US09228227B2
公开(公告)日：2016-01-05
申请号：US14173725
申请日：2014-02-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Zhaochun Ma , Khairuzzaman Bashar Mullah , Robert Eason
IPC: C07D473/18 , C12Q1/68 , C07D405/04 , C07D473/34 , C07H19/16 , C07D239/54 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04
CPC classification number: C07H19/16 , C07D239/54 , C07D405/04 , C07D473/18 , C07D473/34 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/6806
Abstract: Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
Abstract translation: 公开了制备2'，3'-二脱氧核苷酸支持结构的方法，例如2'，3'-二脱氧鸟苷，2'，3'-二脱氧腺苷和3'-脱氧胸苷支持结构。 还提供了使用这些结构的各种方法，例如其用于自动DNA合成和焦磷酸裂解活化聚合的用途。
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公开(公告)号：US20250092261A1
公开(公告)日：2025-03-20
申请号：US18580853
申请日：2022-07-21
Applicant: Life Technologies Corporation
Inventor： Andrew Levitz , Scott Benson , Brian Evans , Khairuzzaman Bashar Mullah
Abstract: The present disclosure relates to dibenzoxanthene compounds that are efficient quenchers of fluorescence, for example in the far red and near infrared spectrum. Applications using the dibenzoxanthene quenching compounds and methods of making same are also described. Also disclosed is a method of detecting or quantifying a target nucleic acid molecule in a sample by polymerase chain reaction (PCR). The compounds have the following formula (I).
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公开(公告)号：US09732112B2
公开(公告)日：2017-08-15
申请号：US14952149
申请日：2015-11-25
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Zhaochun Ma , Khairuzzaman Bashar Mullah , Robert G. Eason
IPC: C07H19/06 , C07H19/16 , C07D473/34 , C07D405/04 , C07D473/18 , C07D239/54 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC classification number: C07H19/16 , C07D239/54 , C07D405/04 , C07D473/18 , C07D473/34 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/6806
Abstract: Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
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