Invention Grant
US09453062B2 Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
有权
葡萄糖依赖性促胰岛素多肽类似物，药物组合物及其用途
- Patent Title: Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
- Patent Title (中): 葡萄糖依赖性促胰岛素多肽类似物，药物组合物及其用途
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Application No.: US14125061Application Date: 2012-06-08
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Publication No.: US09453062B2Publication Date: 2016-09-27
- Inventor: Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
- Applicant: Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
- Applicant Address: CN Beijing
- Assignee: Beijing Hanmi Pharmaceutical Co., Ltd.
- Current Assignee: Beijing Hanmi Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Beijing
- Agency: Fox Rothschild LLP
- Agent Jianming Jimmy Hao
- Priority: CN201110156296 20110610
- International Application: PCT/CN2012/076677 WO 20120608
- International Announcement: WO2012/167744 WO 20121213
- Main IPC: A61K38/22
- IPC: A61K38/22 ; A61K38/00 ; A61K38/28 ; A61K38/26 ; A61K38/16 ; A61P3/04 ; A61P3/10 ; A61P7/12 ; A61P19/10 ; C07K14/605 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C07K14/575 ; C07K14/00
Abstract:
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
Public/Granted literature
- US20140162945A1 GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF Public/Granted day:2014-06-12
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