发明授权
- 专利标题： Delivery of therapeutic agents by a collagen binding protein
- 专利标题（中）： 通过胶原结合蛋白递送治疗剂
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申请号： US14365226申请日： 2012-12-14
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公开(公告)号： US09579273B2公开(公告)日： 2017-02-28
- 发明人: Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
- 申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
- 申请人地址： JP JP
- 专利权人： The Kitasato Institute,National University Corporation Kagawa University,Montefiore Medical Center,The Board of Trustees of the University of Arkansas
- 当前专利权人： The Kitasato Institute,National University Corporation Kagawa University,Montefiore Medical Center,The Board of Trustees of the University of Arkansas
- 当前专利权人地址： JP JP
- 代理机构： Andrus Intellectual Property Law, LLP
- 国际申请： PCT/US2012/069831 WO 20121214
- 国际公布： WO2013/090770 WO 20130620
- 主分类号： A61K8/65
- IPC分类号： A61K8/65 ; A61K8/99 ; A61K38/29 ; C07K14/635 ; A61Q7/00 ; A61K8/66 ; A61K47/48 ; A61K8/49 ; A61K8/64 ; A61K38/17 ; A61K38/18 ; A61K38/19 ; A61K38/30 ; A61K39/44 ; A61Q7/02 ; A61K39/00
摘要：
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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