公开(公告)号：US20190249163A1

公开(公告)日：2019-08-15

申请号：US16283468

申请日：2019-02-22

申请人： The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER ,  NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

发明人： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure ,  Nozomu Nishi

IPC分类号： C12N9/52 ,  A61K47/64 ,  A61K38/29 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  C07K14/50 ,  A61K8/49 ,  A61K8/65 ,  A61Q7/00 ,  A61K8/99 ,  A61Q7/02 ,  A61K8/64 ,  A61K38/18 ,  A61K38/27 ,  A61K39/395 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/51 ,  A61K8/66 ,  A61K38/17 ,  A61K38/19 ,  A61K38/30 ,  A61K39/44

CPC分类号： C12N9/52 ,  A61K8/4913 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/99 ,  A61K38/00 ,  A61K38/179 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/193 ,  A61K38/27 ,  A61K38/29 ,  A61K38/30 ,  A61K39/3955 ,  A61K39/44 ,  A61K47/64 ,  A61K2039/505 ,  A61K2039/6031 ,  A61K2800/57 ,  A61Q7/00 ,  A61Q7/02 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/51 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  C07K2319/31 ,  C07K2319/70 ,  C07K2319/74 ,  C12Y304/24003

摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

公开(公告)号：US09579273B2

公开(公告)日：2017-02-28

申请号：US14365226

申请日：2012-12-14

申请人： The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER ,  NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

发明人： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure ,  Nozomu Nishi

IPC分类号： A61K8/65 ,  A61K8/99 ,  A61K38/29 ,  C07K14/635 ,  A61Q7/00 ,  A61K8/66 ,  A61K47/48 ,  A61K8/49 ,  A61K8/64 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  A61K38/30 ,  A61K39/44 ,  A61Q7/02 ,  A61K39/00

CPC分类号： C12N9/52 ,  A61K8/4913 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/99 ,  A61K38/00 ,  A61K38/179 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/193 ,  A61K38/27 ,  A61K38/29 ,  A61K38/30 ,  A61K39/3955 ,  A61K39/44 ,  A61K47/64 ,  A61K2039/505 ,  A61K2039/6031 ,  A61K2800/57 ,  A61Q7/00 ,  A61Q7/02 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/51 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  C07K2319/31 ,  C07K2319/70 ,  C07K2319/74 ,  C12Y304/24003

摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

摘要翻译： 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 在这些方法中，治疗剂不是PTH / PTHrP受体激动剂或拮抗剂，碱性成纤维细胞生长因子（bFGF）或表皮生长因子（EGF）。 细菌胶原结合多肽片段将药物递送到部分未扭曲或扭曲不足的胶原蛋白部位。 还提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗胶原病的方法。 此外，提供使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 最后，提供通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。

公开(公告)号：US11279922B2

公开(公告)日：2022-03-22

申请号：US16283468

申请日：2019-02-22

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER ,  NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

发明人： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure ,  Nozomu Nishi

IPC分类号： A61K38/29 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  A61K39/395 ,  C12N9/52 ,  A61K8/49 ,  A61K8/65 ,  A61Q7/00 ,  A61K47/64 ,  A61K8/64 ,  A61K8/66 ,  A61K38/30 ,  A61K39/44 ,  A61Q7/02 ,  A61K38/27 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/51 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  A61K39/00 ,  A61K38/00

摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

公开(公告)号：US11001820B2

公开(公告)日：2021-05-11

申请号：US15407589

申请日：2017-01-17

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER ,  NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

发明人： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure ,  Nozomu Nishi

IPC分类号： C12N9/52 ,  A61K38/29 ,  A61K38/19 ,  A61K38/30 ,  A61K39/395 ,  A61K8/49 ,  A61K8/65 ,  A61Q7/00 ,  A61K47/64 ,  A61K8/64 ,  A61K8/66 ,  A61K38/17 ,  A61K38/18 ,  A61K39/44 ,  A61Q7/02 ,  A61K38/27 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/51 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  A61K39/00 ,  A61K38/00

摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

公开(公告)号：US20170204390A1

公开(公告)日：2017-07-20

申请号：US15407589

申请日：2017-01-17

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  The Kitasato Institute ,  MONTEFIORE MEDICAL CENTER ,  NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

发明人： Tulasi Ponnapakkam ,  Sagaya Theresa Leena Philominathan ,  Joshua Sakon ,  Ranjitha Katikaneni ,  Takaki Koide ,  Osamu Matsushita ,  Robert C. Gensure ,  Nozomu Nishi

IPC分类号： C12N9/52 ,  A61K39/395 ,  A61K38/27 ,  A61K38/30 ,  A61K38/17 ,  A61K38/19 ,  C07K14/51 ,  C07K14/50 ,  C07K16/18 ,  C07K14/61 ,  C07K14/475 ,  C07K14/495 ,  C07K14/71 ,  C07K14/535 ,  C07K14/49 ,  C07K14/485 ,  A61K38/18

CPC分类号： C12N9/52 ,  A61K8/4913 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/99 ,  A61K38/00 ,  A61K38/179 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/193 ,  A61K38/27 ,  A61K38/29 ,  A61K38/30 ,  A61K39/3955 ,  A61K39/44 ,  A61K47/64 ,  A61K2039/505 ,  A61K2039/6031 ,  A61K2800/57 ,  A61Q7/00 ,  A61Q7/02 ,  C07K14/475 ,  C07K14/485 ,  C07K14/49 ,  C07K14/495 ,  C07K14/50 ,  C07K14/51 ,  C07K14/535 ,  C07K14/61 ,  C07K14/71 ,  C07K16/18 ,  C07K2319/31 ,  C07K2319/70 ,  C07K2319/74 ,  C12Y304/24003

摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

公开(公告)号：US09908921B2

公开(公告)日：2018-03-06

申请号：US14443558

申请日：2013-10-09

申请人： NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

发明人： Nozomu Nishi ,  Aiko Itoh

IPC分类号： C07K14/47 ,  A61K38/00

CPC分类号： C07K14/4726 ,  A61K38/00 ,  Y02A50/473

摘要： The present invention provides galectin-9 variant having substantially the same bioactivity as in wild-type galectin-9 and being superior in protease stability, solubility, and yield. The galectin-9 variant according to the present invention is a protein including the following NCRD and the following CCRD composed of an N-terminal region and a C-terminal region. The C terminus of the NCRD and the N terminus of the CCRD are directly or indirectly bound to each other. The NCRD is (N1) a peptide composed of an amino acid sequence represented by SEQ ID NO: 1. The N-terminal region of the CCRD is (C-N1) a peptide composed of an amino acid sequence obtained by deletion of 1 to 17 amino acids in an amino acid sequence represented by SEQ ID NO: 3. The C-terminal region is (C-C1) a peptide composed of an amino acid sequence represented by SEQ ID NO: 5.