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公开(公告)号：US11279922B2
公开(公告)日：2022-03-22
申请号：US16283468
申请日：2019-02-22
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号： A61K38/29 , A61K38/17 , A61K38/18 , A61K38/19 , A61K39/395 , C12N9/52 , A61K8/49 , A61K8/65 , A61Q7/00 , A61K47/64 , A61K8/64 , A61K8/66 , A61K38/30 , A61K39/44 , A61Q7/02 , A61K38/27 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , A61K39/00 , A61K38/00
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US20190249163A1
公开(公告)日：2019-08-15
申请号：US16283468
申请日：2019-02-22
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号： C12N9/52 , A61K47/64 , A61K38/29 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K14/50 , A61K8/49 , A61K8/65 , A61Q7/00 , A61K8/99 , A61Q7/02 , A61K8/64 , A61K38/18 , A61K38/27 , A61K39/395 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/51 , A61K8/66 , A61K38/17 , A61K38/19 , A61K38/30 , A61K39/44
CPC分类号： C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US09579273B2
公开(公告)日：2017-02-28
申请号：US14365226
申请日：2012-12-14
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号： A61K8/65 , A61K8/99 , A61K38/29 , C07K14/635 , A61Q7/00 , A61K8/66 , A61K47/48 , A61K8/49 , A61K8/64 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/30 , A61K39/44 , A61Q7/02 , A61K39/00
CPC分类号： C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
摘要翻译： 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 在这些方法中，治疗剂不是PTH / PTHrP受体激动剂或拮抗剂，碱性成纤维细胞生长因子（bFGF）或表皮生长因子（EGF）。 细菌胶原结合多肽片段将药物递送到部分未扭曲或扭曲不足的胶原蛋白部位。 还提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗胶原病的方法。 此外，提供使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 最后，提供通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。
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公开(公告)号：US11001820B2
公开(公告)日：2021-05-11
申请号：US15407589
申请日：2017-01-17
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号： C12N9/52 , A61K38/29 , A61K38/19 , A61K38/30 , A61K39/395 , A61K8/49 , A61K8/65 , A61Q7/00 , A61K47/64 , A61K8/64 , A61K8/66 , A61K38/17 , A61K38/18 , A61K39/44 , A61Q7/02 , A61K38/27 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , A61K39/00 , A61K38/00
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US20170204390A1
公开(公告)日：2017-07-20
申请号：US15407589
申请日：2017-01-17
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号： C12N9/52 , A61K39/395 , A61K38/27 , A61K38/30 , A61K38/17 , A61K38/19 , C07K14/51 , C07K14/50 , C07K16/18 , C07K14/61 , C07K14/475 , C07K14/495 , C07K14/71 , C07K14/535 , C07K14/49 , C07K14/485 , A61K38/18
CPC分类号： C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US10213488B2
公开(公告)日：2019-02-26
申请号：US15386626
申请日：2016-12-21
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US09526765B2
公开(公告)日：2016-12-27
申请号：US14378067
申请日：2013-02-11
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure
IPC分类号： A61K38/10 , A61K38/16 , A61K39/00 , A61K38/39 , C07K14/635 , A61K38/29 , A61K47/48 , A61K38/48
CPC分类号： A61K38/48 , A61K38/29 , A61K47/56 , A61K47/64 , C12Y304/00
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
摘要翻译： 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 此外，提供了通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。
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公开(公告)号：US20170106093A1
公开(公告)日：2017-04-20
申请号：US15386626
申请日：2016-12-21
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure
CPC分类号： A61K38/48 , A61K38/29 , A61K47/56 , A61K47/64 , C12Y304/00
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US20150038423A1
公开(公告)日：2015-02-05
申请号：US14378067
申请日：2013-02-11
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , Montefiore Medical Center
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure
CPC分类号： A61K38/48 , A61K38/29 , A61K47/56 , A61K47/64 , C12Y304/00
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
摘要翻译： 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 此外，提供了通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。
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公开(公告)号：US20190338010A1
公开(公告)日：2019-11-07
申请号：US16517988
申请日：2019-07-22
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , OCHSNER CLINIC FOUNDATION , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
IPC分类号： C07K14/635 , A61K9/00 , C12N9/10 , C12N9/64 , C12N9/50 , A61K35/28 , A61K38/16 , A61K8/64 , A61K8/66 , A61K38/48 , A61K38/29 , A61Q7/00 , C12N9/52
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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