Invention Grant
US09593321B2 L-arabinose isomerase variants with improved conversion activity and method for production of D-tagatose using them
有权
具有改善的转化活性的L-阿拉伯糖异构酶变体和使用它们生产D-塔格糖的方法
- Patent Title: L-arabinose isomerase variants with improved conversion activity and method for production of D-tagatose using them
- Patent Title (中): 具有改善的转化活性的L-阿拉伯糖异构酶变体和使用它们生产D-塔格糖的方法
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Application No.: US15112232Application Date: 2014-04-25
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Publication No.: US09593321B2Publication Date: 2017-03-14
- Inventor: In Seok Oh , Chang Gyeom Kim , Seung Hyun Cho , Seong Bo Kim , Yang Hee Kim , Kyong Yeon Cho , Sung Jae Yang , Jin Ha Kim
- Applicant: CJ Cheiljedang Corporation
- Applicant Address: KR Seoul
- Assignee: CJ Cheiljedang Corporation
- Current Assignee: CJ Cheiljedang Corporation
- Current Assignee Address: KR Seoul
- Agency: Swanson & Bratschun, L.L.C.
- International Application: PCT/KR2014/003658 WO 20140425
- International Announcement: WO2015/133678 WO 20150911
- Main IPC: C12N9/90
- IPC: C12N9/90 ; C12N1/20 ; C12P19/02 ; C12P19/24 ; C12N15/77
Abstract:
The present invention relates to the development of an L-arabinose isomerase variant from Thermotoga neapolitana DSM 5068, which is a kind of thermophile, on the basis of protein molecular modeling. Moreover, the present invention relates to a method of producing D-tagatose from D-galactose by using the enzyme or a microorganism of the genus Corynebacterium expressing the enzyme.
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